摘要
肌肽(β-丙氨酰组氨酸)是最先被发现的最简单生物活性肽(二肽)。肌肽的抗衰老作用已经从离体实验和活体实验得到了证明。最近发现肌肽具有抑制白内障形成的作用,其作用的分子机制尚不十分清楚,可能是通过抗蛋白质的糖基化;抗氧化损伤;抑制蛋白质交联和DNA的损伤机制发挥功能。深入研究肌肽的生物学特性及其抑制白内障形成的机制,将为白内障的药物治疗提供新的方法。
Carnosine （beta-alanyl-L-histidine） was the first and the simplest example of active peptides （actually a dipeptide）. The anti-ageing effect of carnosine had been demonstrated in many studies in vivo and in vitro.More recently,there were some studies verifying the effect of camosine on preventing cataract development.The molecular mechanisms are largely undetermined. The effect of carnosine on delaying the cataract formation may be through anti-glycation of protein,antioxidative impairment, protection protein against cross-links and DNA damage. Further study of carnosine on its biological features and the mechanisms of delaying the progression of eataraetogenesis may provide a new therapy for preventing cataract.
出处
《眼科学报》
2006年第2期85-88,共4页
Eye Science
关键词
肌肽
白内障
糖基化
抗衰老
Carnosine
Cataract
Glyeation
Anti-ageing
