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舌鳞癌中IL-8的表达与微血管生成 被引量：2

Relationship between interleukin-8 expression and angiogenesis in human tongue squamous cell carcinoma
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摘要 目的探讨白细胞介素-8(IL-8)的表达与舌鳞癌血管形成的关系。方法应用免疫组织化学技术检测60例舌鳞癌手术切除标本和10例正常舌黏膜标本中IL-8的表达及肿瘤内微血管密度(iMVD)。结果舌鳞癌标本中36例(60·00%)IL-8呈阳性表达,舌鳞癌iMVD为38·30±12·87;IL-8评分为高级的舌鳞癌组织iMVD高于IL-8评分为阴性和低级的舌鳞癌组织。iMVD与IL-8呈正相关(rs=0·735,P<0·01)。结论IL-8表达与肿瘤内iMVD明显相关,同时与舌鳞癌的临床分期关系密切。 Objective To explore the expression of intedeukin-8 （IL-8） and its relationship between angiogenesis and tumor biological behavior in human tongue squamous cell carcinoma（TSCC）. Methods The expression of IL-8 and the intratumoral microvessel density （iMVD） in 60 cases of human tongue squamous cell carcinoma and 10 cases of normal lingual mucosa were examined by means of immunohistochemical method. Results IL-8 was tested positive in 36 cases of the TSCC （60. 00% ）, and iMVD was 38.30 ± 12. 87 in TSCC. The iMVD in highgrade IL-8 tumors was significantly higher than that in IL-8-negative and low-grade IL-8 tumors, and iMVD was pos- itively correlated with IL-8 expression （ rs = 0. 73, P 〈 0. 01 ）. Conclusion These results suggest that IL-8 expression is significantly associated with iMVD and clinical staging of human tongue squamous ceil carcinoma.
作者 徐文华 周健 陈乔尔 王元银 王银龙 何家才
机构地区 安徽医科大学口腔医学院
出处 《安徽医科大学学报》 CAS 北大核心 2006年第3期275-277,共3页 Acta Universitatis Medicinalis Anhui
关键词 癌 鳞状细胞 免疫组织化学 白细胞介素8 新生 血管化 病理性 carcinoma, squamous cell immunohistochemistry interleukin-8 neovascularization, pathologic
分类号 R739.8 [医药卫生—肿瘤] R364.3 [医药卫生—病理学]
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参考文献9

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二级参考文献8

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共引文献2

同被引文献17

  • 1Mitsushige Sugimoto,Yoshio Yamaoka,Takahisa Furuta.Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer[J].World Journal of Gastroenterology,2010,16(10):1188-1200. 被引量：61
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引证文献2

二级引证文献8

安徽医科大学学报
2006年 第3期

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