摘要
目的:探讨结直肠癌中P-糖蛋白(P-gp)、谷胱甘肽-S-转移酶(GST-π)和DNA拓扑酶Ⅱ(TopoⅡ)的表达及临床意义。方法:应用SupervisionTM法检测67例结直肠癌组织中P-gp、GST-π和TopoⅡ的表达。结果:P-gp、GST-π和TopoⅡ的表达阳性率分别为64.2%(43/67),59.7%(40/67)和61.2%(41/67)。P-gp、GST-π和TopoⅡ的表达与年龄、性别、肿瘤大小、发病部位、组织学分级、临床分期及有无淋巴结转移无关(P>0.05)。结论:应用免疫组化法检测结直肠癌组织中P-gp、GST-π和TopoⅡ的表达,对结直肠癌的化疗药物的选择和判断预后具有显著的临床意义。
Objective： To detect the expression of P - glycoprotein （P - gp）, glutathione S - transfemse （GST - π）, and Topoiso - meraseⅡ （Topo Ⅱ） and to evaluate its clinical significance in colorectal carcinoma. Methods： Supervision^TM immunohistochemical technique was performed to investigate the expression of P - gp, GST - π, Topo Ⅱ in 67 cases colorectal carcinoma. Results： The positive rates of expression of P - gp, GST - π, Topo Ⅱ were 64.2 % （43/67）, 59.7 % （40/67） and 61.2 % （41/67）, respectively. The expression rate was no related to sex, age, site, histological grading, clinical staging and metastasis of lymph nodes （P 〉 0.05）. Conclusion： The detection of P - gp, GST - π and Topo Ⅱ by immunohistochemistry is of important clinical significance to select chemotherapy and to judge prognosis in colorectal carcinoma.
出处
《医学理论与实践》
2006年第6期626-627,共2页
The Journal of Medical Theory and Practice
