摘要
目的从生命质量的角度评价耐多药肺结核(MDR-TB)患者的健康状况及变化。方法用SF-36量表对100例MDR-TB患者和100名正常人进行生命质量测评,对完成疗程92例患者治疗前、治疗3个月及治疗1年的生命质量总评分及各维度得分进行配对t检验、多元方差分析评价疗效。对生命质量的影响因素进行单因素分析和多因素逐步回归分析。结果MDR-TB患者的生命质量总分及8个维度得分与正常对照组相比有显著性差异(P<0.01);治疗3个月或治疗1年的生命质量总分及8个维度的得分明显高于治疗前且有显著性差异(P<0.01);治疗1年后的总分及PF、PR、GH、VT、SF、ER、MH 7个维度较对照组低并有显著性差异(P<0.05)。影响MDR-TB患者生命质量的主要因素是:文化程度、耐药数目、WBC降低。结论MDR-TB患者的Qol均显著降低,治疗后生命质量明显提高,但治疗1年后仍不能恢复正常。早期强化期治疗能够明显提高MDR-TB患者的Qol。影响MDR-TB患者生命质量的主要因素是:文化程度、耐药数目、WBC降低。
Objective To evaluate health and curative effect of patients with muhi-drug resistant pulmonary tuberculosis （MDR-TB） from the angle of the quality of life （Qol）. Methods To measure and evaluate Qol for 100 patients with MDR-TB and 100 natural persons using SF-36 instrument. To state and accomplish 92 patients Qol. The investigation time was before,3 months after treatment and 1 year after treatment. The changes of Qol scores were evaluated in total and many domains To evaluate curative effect using paired t test and analysis of variance. Single and multiple stepwise regression analysis were made to evaluate factors affecting Qol. Results Between the patients with MDR-TB and the control in the total Qol scores and eight domains,there were significant differences （ P 〈 0.01 ）, total Qol scores and eight domains in 3 months or 1 year after treatment were higher than before therapy, there were significant differences（ P 〈 0.01）. Between 1 year after therapy in the total Qol scores and PF, PR, GH, VT, SF, ER, MH＇s domains were lower than control groups, there were significant differences（ P 〈 0.05） .The main factors affecting the Qol of patients with MDR-TB were cultural level, kinds of drug resistant and reduction of counts of white blood cell. Conclusion There were comprehensive reduces in the quality of life of patients with MDR-TB. The quality of life of patients with MDR-TB had increased significantly but hadn＇ t recovered completely 1 year after therapy. Early intensive therapy could increase the quality of life of patients with MDR-TB. The main factors affecting the Qol of patients with MDR-TB are cultural level, kinds of drug resistant and reduction of counts of white blood cell.
出处
《中国防痨杂志》
CAS
2006年第3期139-142,共4页
Chinese Journal of Antituberculosis
基金
武汉市科技局基金资助项目
关键词
抗药性
多药
结核肺
生命质量
Drug resistant, multiple
Pulmonary tuberculosis
Quality of life
