摘要
目的:观察辛夷挥发油(VOMbP)对过敏性鼻炎豚鼠、大鼠的作用。方法:采用TD I对豚鼠、大鼠分别进行造模,观察症状体征、光镜下鼻黏膜组织形态学变化以及肥大细胞(大鼠)、嗜酸性粒细胞(豚鼠)计数。结果:VOMbP治疗组鼻痒、喷嚏、清涕、鼻黏膜厚度以及豚鼠嗜酸性粒细胞浸润、大鼠肥大细胞浸润明显改善。结论:VOMbP能缓解局部症状,改善局部黏膜的充血、水肿,减少嗜酸性粒细胞和肥大细胞在炎症局部的浸润。
Objective： To determine the therapeutic effects of VOMbP on Allergic Rhinitis （AR） in guinea - pig or in rat. Methods ：AR was induced in guinea - pigs with TDI, and also in rat. The changes in symptoms, morphological features of nasal mucosa under fight microscopy and number of mast cell in rat nasal mncosa were observed,while number of eosinophil in guinea - pig nasal mucosa was observed. Results： VOMbP inhibited the increase in nasal symptoms such as sneezing, sniveling and nasal rubbing. And other typical manifestation of AR including nasal mucosal thickness and increased eosinophil（ guinea - pig）/mast cell （rat） number in nasal mucosa were significantly inhibied in VOMbP group. Conclusion： The therapeutical effects of VOMbP were as follows ： （ 1 ） inhibiting the increase in nasal allergic symptoms; （2） relieving the degree of the nasal mucosal engorgement and edema; （3） reducing the increased number and infiltration of eosinophil or mast cell.
出处
《中医药学刊》
CAS
2006年第6期1031-1032,共2页
Study Journal of Traditional Chinese Medicine
基金
四川省教育厅资助课题(2003)
成都中医药大学校基金课题(2002)
关键词
辛夷挥发油
动物模型
过敏性鼻炎
嗜酸性粒细胞
肥大细胞
flos magnoliae volatile oil（VOMbP）
animal model
allergic rhinitis（AR）
eosinophil
mast cell
