摘要
目的:探讨高泌乳素血症对女性精神分裂症患者疗效及生活质量的影响。方法:将女性精神分裂症患者82例,分为研究组42例(伴有高泌乳素血症)及对照组40例(不伴高泌乳素血症)。以阳性与阴性症状量表(PANSS)、副反应量表(TESS)、生活质量综合评定问卷(GQOLI)评定的疗效、不良反应及生活质量。观察6个月。结果:第6个月末,研究组PANSS减分低于对照组(P<0.05)。GQOLI总分、躯体健康维度、心理健康维度、社会功能维度较入组时分值亦下降(P均<0.01);与对照组比较分值显著下降(P<0.01)。结论:伴有高泌乳素血症的女性精神分裂症患者的疗效差,生活质量下降。
Objective：To investigate the influences of hyperprolactinemia on the efficacy and life quality of female patients with schizophrenia. Method： 82 female schizophrenics were divided into research group including 42 patients with hyperprolactinemia and controlled group including 40 patients without hyperprolaetinemia. The positive and negative syndrome scale （PANSS）, treatment emergent symptom scale （TESS）, general quality of life inventory （GQOLI） were assessed by all subjects to determine the efficacy, side effects and life quality respectively for 6 months, Results： At the end of 6 th month, the reduction rate of PANSS was significantly lower in reseach group than in controls （ P 〈 0.05）. Compared with the beginning, the total score of GQOLI and factor scores of physical function, menial health and social function decreased significantly （ P 〈 0.01 ）. Conclusion： Female schizophrenics with hyperprolactinemia have poorer efficacy and lower life quality than those without hyperprolactinemia.
出处
《临床精神医学杂志》
2006年第3期142-143,共2页
Journal of Clinical Psychiatry
