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血管生长抑制素癌抑素研究进展

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摘要 肿瘤生长和动脉粥样硬化的发展与新生血管的形成有一定的关系,该文就一种新的血管生长抑制素癌抑素(canstatin)在血管内皮细胞的增殖、迁移和凋亡中作用以及在肿瘤、心血管疾病防治作用和意义作一综述。
作者 鲁立 江渝
出处 《国际检验医学杂志》 CAS 2006年第6期553-555,共3页 International Journal of Laboratory Medicine
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参考文献13

  • 1Kamphaus GD, Colorado PC, Panka DJ, et al. canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. J Biol Chem, 2000, 275(2): 1209-1215.
  • 2Habeck M. Wielding more power over angiogenesis. Mol Med Today. 2000. 6(4): 138-139.
  • 3He GA, Luo JX, Zhang TY, et al. The C-terminal domain of canstatin suppresses in vivo tumor growth associated with proliferation of endothelial cells. Biochem Biophys Res Commun, 2004, 318(2):354-360.
  • 4侯卫红,王天云,柴玉荣,袁保梅,侯桂琴,王建民,薛乐勋.小鼠canstatin及其N端片段在大肠杆菌BL21中的表达[J].遗传,2004,26(5):658-662. 被引量:2
  • 5He GA, Luo JX, Zhang TY, et al. Expression and purification of the N-domain of human canstatin and its bioactivity. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003, 35(5):483-487.
  • 6He GA, Luo JX, Zhang TY, et al. canstatin-N fragment inhibits in vitro endothelial cell proliferation and suppresses in vivo tumor growth. Biochem Biophys Res Commun, 2003, 312(3): 801-805.
  • 7Panka DJ, Mier JW. canstatin inhibits Akt activation and induces Fas-dependent apoptosis in endothelial cells. J Biol Chem, 2003,278(39): 37632-37636.
  • 8Liu G, Guibao CD, Zheng J. Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase. Mol Cell Biol, 2002, 22(8): 2751-2760.
  • 9Panka DJ, Mano T, Suhara T, et al. Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells. J Biol Chem, 2001, 276(10): 6893-6896.
  • 10Sudhakar A, Sugimoto H, Yang C, et al, Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci USA, 2003, 100(8): 4766-4771.

二级参考文献4

  • 1O'Reilly MS,Holmgren L,Shing Y,et al.Angiostatin:a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma[J].Cell,1994,79(2):315-328.
  • 2O'Reilly MS,Boehm T,Shing Y,et al.Endostatin:an endogenous inhibitor of angiogenesis and tumor growth[J].Cell,1997,88(2):277-285.
  • 3Kamphaus GD,Colorado PC,Panka DJ,et al.Canstatin,a novel matrix-derived inhibitor of angiogenesis and tumor growth[J].J Biol Chem,2000,275(2):1209-1215.
  • 4李浪,冯建章,郑文岭.血管生成抑制素canstatin的新发现[J].中国病理生理杂志,2002,18(7):862-864. 被引量:6

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