摘要
目的观察卡托普利的时辰疗法与传统疗法对杓型高血压患者的降压作用。方法80例杓型高血压患者,随机分为治疗组和对照组,采用不同时辰给药观察卡托普利的降压效应。结果两组用药后夜间平均收缩压、夜间平均舒张压、夜间收缩压下降值、夜间舒张压下降值、夜间收缩压下降百分率、夜间舒张压下降百分率、24h收缩压峰值、24h舒张压峰值比较,差异均有显著性(均为P<0.05);对照组与治疗组的治疗有效率分别为75.0%、72.5%,二者比较差异无显著性(P>0.05);两组24h平均收缩压、24h平均舒张压、日间平均收缩压、日间平均舒张压比较差异无显著性(P>0.05)。结论卡托普利在治疗杓型高血压上传统疗法及时辰疗法均有效,但时辰给药可以避免血压在高峰时段过高和低谷时段过低,保持血压平稳,减轻对靶器官的损害。
Objective To observe the effect of chronotherapy of Captopril in dipper hypertension. Methods 80 patients with dipper hypertension were randomly divided into two groups： treatment group and control group. And then the antihypertensive effect was observed at different time after Captopril therapy. Results After administration there was significant difference between two groups in average systolic pressure and diastolic pressure at night,systolic pressure and diastolic pressure decreased value at night, systolic pressure and diastolic pressure decreased percentage at night, peak of systolic pressure and diastolic pressure in 24 h （ P 〈 0.05 ）. The results showed that there was no significant difference between two groups in effective rate （75.0% in control group and 72.5% in treatment group ）, average systolic pressure and diastolic pressure in 24 h, average systolic pressure and diastolic pressure in daytime （ P 〉 0.05 ）. Conclusion Captopril has effect in treatment of dipper hypertension with either traditional treatment or chronotherapy. But chronotherapy may keep blood pressure steady by avoiding over high or low when blood pressure reaches the highest or lowest level and slow down the damage of hypertensive target organs.
出处
《中国医药》
2006年第4期193-195,共3页
China Medicine
