摘要
目的:研究六味地黄方对高脂血症大鼠血管内皮细胞的保护作用。方法:高脂饮食建立高脂血症大鼠模型,观察大鼠血脂、血清超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、一氧化氮合酶(NOS)及外周血循环内皮细胞(CEC)的变化。结果:高脂模型组血清TC、TG、LDLC、MDA、CEC均明显升高,HDLC、SOD、NO、NOS显著下降;六味地黄方可降低模型大鼠血清TC、TG、LDLC、MDA、CEC,升高HDLC、SOD、NO、NOS。结论:六味地黄方具有调节脂质代谢、抗脂质过氧化反应、升高NO水平,保护血管内皮细胞的作用。
Objective： To determine the protective effects of Liuweidihuang Formula （LWDHF） on endothelial cells in the experimental hyperlipidemic rats. Methods： The hyperlipidemic model in rats was set up by feeding high cholesterol diet. Serum lipid, superoxide dismutase （SOD） , malondialdehyde （MDA） , nitric oxide （NO） , nitricoxide synthase （NOS） and circulating endothelial cells （ CEC ） in peripheral blood were measured. Result： Serum TC, TG, LDL-C, MDA concentration and CEC were significantly decreased but serum HDL-C, SOD, NO, NOS levels and CEC were evidently increased in LWDHF treated groups as compared with those of hyperlipidemic group（ P 〈0.05 or P 〈 0.01 ）. Conclusion： The results indicate that LWDHF can modulate lipid metabolism, inhibit lipid peroxidation ,increase NO, thus might protect vascular endothelial cells.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2006年第1期5-7,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
江苏省教育厅自然科学基金资助项目(02KJB360005)
江苏省中医药局资助项目(H004)
江苏省科技厅基金项目(BK2001125)
国家自然科学基金项目(30271577)
