摘要
目的探讨MK和CD105的表达与大肠癌生物学行为的关系及对预后的意义。方法采用免疫组织化学方法检测50例大肠癌组织MK和CD105表达水平,并对其与大肠癌临床病理特征的关系进行统计学分析。结果本组50例中,MK阳性表达率为72%。MK为阳性时CD105标记的MVD值(71.73±6.99)明显高于MK为阴性组的MVD值(66.09±7.49)(P<0.05)。两者的表达均与大肠癌的Duke's分期、淋巴结转移、浸润深度有关。结论MK的阳性表达与大肠癌的发生、发展和预后密切相关,可联合CD105作为一组有价值的肿瘤标记和预后指标。
Objective To investigate the relationship between the expression of midkine（MK） and CD105 in colorectal carcinoma and the biological behavior and prognosis of colorectal carcinoma. Methods The expression of midkine（MK） and CD105 were detected by immunohistochemical technique in 50 colorectal carcinoma specimens. The relationship of their expression to clinicopathological characteristics was statistically analyzed. Results Of the 50 cases, the positive expression of MK was 36 cases（72%）. When MK expression was positive in tumors, MVD （71.73 ± 6. 99） signed with CD105 was significantly higher than the tumors with MK negative expression（66. 09 ± 7. 49） （P〈0. 05）. The expression of MK and CD105 were correlated closely with Duke＇s pathologic stage, lymph node metastasis and the depth of invasion. Conclusion MK positive expression is closely correlated with tumor development, progression and prognosis in colorectal carcinoma, so may be used as a valuable tumor marker and prognostic indicator together with CD105.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2006年第6期425-427,F0003,共4页
Cancer Research on Prevention and Treatment
关键词
大肠癌
中期因子
微血管
预后
Colorectal carcinoma
Midkine
Microvessel
Prognosis
