摘要
目的探讨胃癌组织中Her-2/neu和E-cadherin的表达情况及在胃癌发生发展及侵袭转移中的作用。方法应用SP法研究112例胃癌及40例正常胃黏膜组织中Her-2/neu和E-cadherin的表达。结果胃癌组织中Her-2/neu阳性表达率为20·5%(23/112),E-cadherin阳性表达率为34·0%(38/112);40例正常胃黏膜阳性表达率Her-2/neu为5·0%(2/40),E-cadherin为100·0%(40/40)。胃癌Her-2/neu阳性表达率显著高于正常胃黏膜组织,χ2=5·17,P<0·05;正常胃黏膜E-cadherin阳性表达率显著高于胃癌阳性表达率,χ2=18·11,P<0·01。胃癌组织中Her-2/neu的表达与胃癌分化程度(χ2=4·82,P<0·05)、TNM分期(χ2=5·37,P<0·05)、淋巴结转移数(χ2=6·42,P<0·05)及浆膜浸润(χ2=7·30,P<0·01)显著相关。胃癌组织中E-cadherin的表达与胃癌分化程度(χ2=14·40,P<0·01)和淋巴结转移(χ2=29·27,P<0·01)呈负相关,但与TNM分期(χ2=1·31,P>0·05)和有无浆膜浸润(χ2=2·62,P>0·05)均无显著相关。结论Her-2/neu和E-cadherin在胃癌的发生发展及侵袭转移中起重要作用,对两者的检测有助于对患者预后的判断。
OBJECTIVE: To study the significance of Her-2/neu and E-cadherin the initiation, development, invasion and metastasis of gastric carcinoma. METHODS: The expressions of Her-2/neu and E-cadherin in 112 cases of gastric carcinoma (GC) and 40 cases of normal control were studied with SP immunohistochemical method. RESULTS: The positive rates of Her-2/neu and E-cadherin in GC were 20.5% (23/112) and 34.0% (38/112) respectively. While the positive rates of Her-2/nen and E-cadherin in normal control were 5.0% (2/40), 100.0% (40/40) respectively. The expression of Her-2/neu in GC was higher than that in normal control (X^2 = 5.17, P 〈 0.05) and the expression of E-cadherin in normal control was higher than that in GC (X^2 = 18.11, P 〈 0.01). The expression of Her-2/neu was significantly correlated with the clinicopathological factors such as differentiation (X^2 = 4.84, P 〈 0.05), lymph node metastasis (X^2 = 6.42, P 〈 0.05), clinical stage (X^2 = 5.37, P 〈0.05) and depth of invasion (X^2 = 7.30, P 〈 0.01). The expression of E-cadherin was significantly correlated with differentiation (X^2 = 14.40, P 〈 0.01) and lymph node metastasis (X^2 = 29.27, P 〈 0.01), but no correlation was observed between E-cad- herin and depth of invasion (X^2 = 2.62, P 〈 0.05) and clinical stages (X^2 = 1.31, P 〈 0.05). CONCLUSIONS: Her-2/neu and E-cadherin may play important roles in initiation, development, invasion metastasis of gastric carcinoma. They are useful markers of the patients with GC.
出处
《中华肿瘤防治杂志》
CAS
2006年第11期847-850,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
胃肿瘤
受体
表皮生长因子
钙粘着糖蛋白
免疫组织化学
肿瘤转移
stomach neoplasms
receptor, epidermal growth factor
cadherins
immunohistochemistry
neoplasms metastasis