摘要
5硝基2氨基苯甲腈与环己酮反应可以按不同的反应机理得到7硝基他克林和2H3,1苯并噁嗪衍生物。研究了不同条件下生成二者的竞争反应工艺条件及反应机理,发现用三氯化铝作催化剂时,产物以7硝基他克林为主;改用无水氯化锌作催化剂时,产物以2H3,1苯并噁嗪衍生物为主。前者的生成是动力学控制,后者的生成是热力学控制。
Owing to the different mechanism of the reactions between 5-nitro-2-aminobenzylnitrile with cyclohexanone, either 7-nitrotacrine or 2H-3,1-benzoxazine derivatives can be obtained. If using AlCl3 as catalyst, the product is mainly 7- nitrotacrine, if using anhydrous ZnCl2 as catalyst, the product is mainly 2H-3,1-benzoxazine. It is found that the formation of 7-nitrotacrine is controlled by dynamic factor, whereas the formation of 2H3,1-benzoxazine is controlled by thermodynamic factor.
出处
《精细与专用化学品》
CAS
2006年第12期21-24,共4页
Fine and Specialty Chemicals
