摘要
光学活性二醇（１Ｒ，２Ｒ）－（＋）－１，２－二苯基－１，２－乙二醇（Ⅲａ）和（２Ｒ，３Ｒ）－（－）－１，１，４，４－四苯基－２，３－（缩丙酮）－１，４－丁二醇（Ⅲｂ）分别修饰Ｔｉ（ＯＰｒｉ）３Ｃｌ，再与甲基锂和乙基锂进行烷基化，制备出新的手性有机钛试剂Ⅱａ和Ⅱｂ，然后与苯甲醛进行加成，所得１－苯基乙醇（Ⅳａ）和１－苯基丙醇（Ⅳｂ）的光学收率分别为２５～６５％ｅ．ｅ．和１０～２０％ｅ．ｅ．。
Addition of optically active alkyltitanium reagents Ⅱa and Ⅱb to benzaldehyde gave (+) 1 phenylethanol(Ⅳa) with 25～65%e.e. and (+) 1 phenylpropanol(Ⅳb) with 10～20%e.e. Reagents Ⅱa and Ⅱb were prepared from chlorotris(2 propoxy)titanium modified by (1R,2R) (+) 1,2 diphenylethane 1,2 diol(Ⅲa) and (2R,3R) (-) 1,1,4,4 tetraphenyl 2,3 (2 propylidenedioxy)butane 1,4 diol(Ⅲb) and then reacted with alkyllithium, respectively. The effects of asymmetric addition reaction conditions and enantioselectivity by the C 2 symmetric diols were discussed.
出处
《合成化学》
CAS
CSCD
1996年第3期257-260,共4页
Chinese Journal of Synthetic Chemistry
关键词
加成反应
光学活性
有机钛
试剂
苯甲醛
Asymmetric addition, Optically active organotitanium reagents, Chiral C 2 diols .
