摘要
目的探讨环氧化酶-2(COX-2)和p53在人大肠癌中的表达及与临床病理特征的关系。方法应用免疫组织化学染色法检测72例经手术切除原发性大肠癌组织和21例正常大肠黏膜组织中COX-2和p53的表达。结果大肠癌组织中COX-2和p53阳性表达率分别为70.8%和62.5%。与正常大肠黏膜组织中阳性表达率28.6%和23.8%相比较,差异均有统计学意义(P<0.05)。COX-2在有淋巴结转移组、肝转移组、C与D期组中表达率均高于相应对照组,而p53在有淋巴结转移组、肝转移组、低分化组中表达率高于相应对照组,且差异均有统计学意义(P<0.05)。COX-2的表达与p53的表达呈正相关性(r=0.642,P<0.01)。结论COX-2和p53的异常表达可能是大肠癌发生、发展过程中的一个重要环节。COX-2和p53的异常表达在大肠癌的发生、发展中起协同作用,p53突变可能是大肠癌中COX-2过表达的因素之一。
Objective To investigate the expressions of COX-2 and p53 in human colorectal carcinoma and their correlations with clinicopathological features of colorectal carcinoma. Methods The expressions of COX-2 and p53 were determined by immunohistochemical staining in 72 surgical specimens of colorectal carcinoma and 21 normal mucosal tissues. Results The positive rates of COX-2 and p53 in colorectal carcinoma were 70.8 % and 62.5 %, respectively. The differences between carcinoma group and normal tissues group were statistically significant（P 〈 0.05）. The expressions of COX-2 were significantly higher in lymph node metastasis group, liver metastasis group, C, D group than in their counterparts （P 〈 0.05）, the expressions of p53 were significant in lymph node metastasis group, liver metastasis group, poor differentiation group than in their counterparts （P 〈 0.05）. There was a significant correlation between the expressions of COX-2 and p53（P 〈 0.01）. Conclusions The abnormal expressions of COX-2 and p53 played a role in the carcinogenesis and development of eolorectal carcinoma. The expressions of COX-2 and p53 showed a positive correlation in the carcinogenesis and development of colorectal carcinoma. The mutation of p53 might be one of the important factors in the COX-2 overexpression of colorectal carcinoma.
出处
《肿瘤研究与临床》
CAS
2006年第6期383-385,共3页
Cancer Research and Clinic
