摘要
人体内影响泌尿系结石形成的细菌有2类:一类诱发尿石形成,主要是通过分解尿素使尿液pH升高、加重尿路感染、降低尿石抑制剂浓度、破坏尿路粘膜酸性粘多糖保护层从而促进晶体滞留;另一类抑制尿石的形成,这些细菌(主要为食草酸杆菌、乳酸杆菌和粪肠球菌等草酸分解菌)参与外源性草酸代谢,降低尿草酸浓度。探讨了该领域所面临的问题和将来的发展方向。
There are two populations of bacteria to affect the formation of urinary stones in humanity. The first one can promote the formation of urinary stone by increasing urinary pH, decreasing concentration of urinary inhibitors, and damaging the protective urothelial glycosaminoglycan layer. The second inhibit the formation of urinary stones. These bacteria （ mainly the intestinal oxalate degrading bacteria such as Oxalobacter formigenes, lactic acid bacteria, Enterococeus faecalis etc） can decrease urinary oxalate concentration by regulating exogenous oxalate. The problems faced and the developing direction were also indicated.
出处
《微生物学通报》
CAS
CSCD
北大核心
2006年第3期157-160,共4页
Microbiology China
基金
国家自然科学基金资助项目(No.20471024)
广东省科技攻关项目(No.2005B30701003)
关键词
细菌
微生物
泌尿系结石
生物矿化
Bacteria, Microorganism, Urinary stones, Biomineralization
