摘要
首次合成了酰基异硫氰酸酯４，并将其与各种芳胺、脂肪胺和肼衍生物加成，得到了２２种未见文献报道的含双环笼状磷酸酯结构的酰基硫脲化合物（５ａ－５ｘ）。４与丁胺反应未得到预期的加成产物，而得到相应的取代产物６。研究了５的结构。
Twenty-two carbonyl thioureas derivatives──N-(1-oxo-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane- 4- carbonyl)- N'- aryl(alkyl)thioureas 5a─5x were synthesized by the addition reaction of 1-oxo-4-carbonyl isothiocyanate-2, 6 , 7-trioxa-1-phosphabicyclo[2. 2 .2]octane 4 with various amines.The IR and ￣1H NMR spectra of 5 show that most of them exist in the keto-thioketo form and only a few of them have keto-thioenol tautomer.IR and 1H NMR data also indicate that compounds 5 have intramolecular hydrogen bond. The structures of 5 were also confirmed by elementary analysis and MS. The biological activities of 5 and the crystal structure of compound 5q are being tested.
出处
《高等学校化学学报》
CSCD
北大核心
1996年第9期1394-1398,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
关键词
磷酸酯
异硫氰酸酯
胺
硫脲
加成反应
Caged bicyclic phosphates
Isothiocyanate
Amines
Thioureas
Addition
