摘要
目的探讨外周血造血干细胞移植(PBSCT)中出血性膀胱炎(HC)的发病机制及防治方法。方法19例PBSCT患者进行水化、利尿、碱化、应用美司钠及抗病毒治疗,对HC的危险因素和临床疗效进行分析。结果19例PBSCT患者中,1例出现HC。结论HC的发生除与环磷酰胺、马利兰、全身照射的损害有关外,还与移植物抗宿主病及病毒感染有关。在常规水化、碱化、利尿基础上加用美司钠和抗病毒治疗,可降低HC的发生率。
OBJECTIVE： To study the pathogenesis, prevention and treatment of the hemorrhagic cystitis（HC） in the peripheral blood stem cell transplantation（PBSCT）recipients.METHODS： 19 patients undertaking PBSCT were given treatment of hyperhydration, diuresis, alkalinizing, mensa and antivirus medicine, The clinical risk factors and outcomes of the HC were analyzed ,RESULTS： Only 1 of the 19 patients developed HC.CONCLUSION： Besides some chemiotherapy regimens such as cyclophosphamide, busulfan and TBI, GVHD and virus infection are the risk factors of HC.And extra use of mensa and antivirus medicine combined with routive hyperhydration,diuresis and alkalinizing can decrease the incidence of HC.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第12期932-933,共2页
China Pharmacy
关键词
造血干细胞移植
出血性膀胱炎
防治
Hematopoleyic stem cell transplantation
Hemorrhagic cystitis
Prevention and treatment
