摘要
目的比较外源性肺表面活性物质(PS)的不同应用方式治疗新生儿呼吸窘迫综合征(NRDS)的疗效和安全性。方法将36例NRDS患者随机分为两组,每组18例,均经气管导管使用一种天然的肺表面活性物质Curosurf(固尔苏)注射液,一组按不同体位分次注药,另一组取仰卧位一次注药。比较两组用药前后血气指标、用药后机械通气时间、总用氧时间、并发症的发生率。结果两组用药后48h各氧合及肺功能指标较用药前明显改善(P<0.05)。两组间在用药及用药后2、8、24h血气指标比较差异均无显著性意义(P>0.05)。机械通气和总用氧时间、并发症发生率两组间的差异亦无显著性意义(P>0.05)。结论PS的不同应用方式在治疗NRDS临床疗效及安全性等方面基本一致。
Objective To compare the efficacy and safety of pulmonary surfactants （PS） by two different administration means in treating neonatal respiratory distress syudrome （ NRDS）. Methods 36 neonates with NRDS were divided into 2 groups randomly, the means of administration in all patients was through tracheal tube. Neonates in one group were given curosurf in several times with different posture. Neonates in another group were given in one time with supine position. Blood gas analysis, the duration of mechanical ventilation, hours of oxygen requirement and incidence of complication before and after treatment were analyzed and compared. Results After treatment, the oxygenation and lung function of two groups improved respectively（ P 〈 0.05 ）, the differences of those index were no significant between two groups （ P 〉0.05）. Conclusions Pulmonary surfactant is effective and safe for treating NRDS, and have no relationship with the means of administration.
出处
《实用全科医学》
2006年第4期413-414,共2页
Applied Journal Of General Practice
