摘要
目的探讨不同剂量埃索美拉唑对胃食管反流病(GERD)的治疗效果。方法选择63例门诊及住院经电子胃镜证实为GERD患者(洛杉矶分级为A级和B级)随机分为三组。A组20例予以埃索美拉唑20mg,每日2次;B组21例予以埃索美拉唑40mg,每日2次;C组22例予以埃索美拉唑20mg,每日2次,睡前40mg,分别观察患者治疗前及治疗后8周临床症状改善情况;治疗8周后行电子胃镜检查观察愈合率。结果三组临床症状均有明显改善,症状记分较治疗前显著下降(P均<0.01)。C组在症状消失率、总有效率以及内镜下食管炎愈合率和总有效率方面均高于A、B组,但差异无显著性。结论埃索美拉唑是治疗轻、中度GERD患者有效的药物,尤其加用夜间酸突破治疗,效果更佳。
Objective To compare clinical efficacy of different dosage of Esomeprazole in treatment of gastroesophageal reflux disease （GERD）. Methods Sixty - three patients with GERD proven by gastroscope were enrolled in this study. They were randomly allocated to three groups, group A, B and C. Twenty cases in group A received therapy with Esomeprazole 20mg, twice a day; twenty - one cases in group B were given Esomeprazole 40mg, twice a day; twenty- two cases in group C were given Esomeprazole 20mg, twice a day, 40mg before night sleeping. Before treatment and 8 weeks after treatment, the clinical symptoms and signs were assessed, 8 weeks after the treatment, a gastroscope was used to examine the healing state. Results Symptom relief was obtained in all the three groups, by comparison to treatment before, the symptom scores were lower （ P 〈0. 01 ）. In comparison to groups A and B, higher symptom free rate, total effective rate, and endoscopic esophogitis healing rate and total effective rate were found, but there were no statistically significant differences. Conclusion Esomeprazole is an effective drug in treatment of mild, moderate GERD, a better result was obtained plus nocturnal acid breakthrough treatment.
出处
《右江民族医学院学报》
2006年第3期360-362,共3页
Journal of Youjiang Medical University for Nationalities
关键词
胃食管反流饴疗
埃索美拉唑
剂量效应关系
药物
gastroesophageal reflux/therapy
esomeprazole
dose - response relationship
