摘要
目的:观察慢性肾功能衰竭(CRF)患者全段颈动脉粥样硬化病变,探讨CRF患者全段甲状旁腺素(iPTH)与颈动脉内膜—中层厚度(IMT)的相关性。方法:对46例CRF患者和23例正常对照分别检测颈动脉平均IMT、最大IMT,以及血流动力学参数收缩期峰值血流速度(SPV),舒张末期血流速度(DEV)和阻力指数(RI),罗氏Elecsys2010全自动电发光免疫分析仪测iPTH。同时记录所有研究对象的临床及生化指标。结果:CRF患者的颈动脉平均IMT、最大IMT、斑块发生率、RI与正常对照组相比明显升高(P<0.01,0.01,0.05,0.05),两组间iPTH有明显差异(278.83±94.38vs60.54±8.42,P<0.01),CRF患者的iPTH与颈动脉平均IMT(r=0.620,P<0.01)、最大IMT(r=0.537,P<0.01)、RI(r=0.342,P<0.05)相关,多因素相关分析,影响颈动脉平均IMT的因素有年龄i、PTH、钙磷乘积、血肌酐和胆固醇。结论:CRF患者血清iPTH与动脉粥样硬化病变有关,可能是加速其动脉粥样硬化的危险因素。
Objective：To study the relationship of the parathyroid hormone with atherosclerosis of carotid artery by measure the serum level of intact parathyroid hormone （iPHT） and the carotid intimar media thickness （IMT）. Methods： 46 patients with CRF and 23 control persons were collected and the indicators included the mean IMT,maxium IMT and plaque of bilateral carotid arteries by color ultrasound, the blood velocity （DEV）, the blood resist index （RI）, iPHT and the clinical indices and other blood indicators. Results：The mean IMT,the maxium IMT,RI,ncidence of coratid plaque of the CRF increased significantly comoared to the control group （P0.01.0. 01,0. 05,0. 05）. The iPTH showed obvious differences between the CRF group and the control group （278.83 ± 94.38 vs 60.54 ± 8.42, P 〈 0.01）. The correlation of iPTH to the mean IMT,maxium IMT and RI was positvely significant. Respectively （ γ = 0. 620. P 〈 0.01 ： γ = 0. 537, P 〈 0.01 ： γ = 0. 342, P 〈 0. 05）. The influence factors of mean IMT included the age, iPTH, calcium - phosphate product, serum creatinine and cholesterin by the multiple regression analysis. Conclusion： The iPTH was related to the atherosclerosis in CRF patients and might be a dangerous infactor to accelerate tne atherosclerosis.
出处
《内蒙古医学杂志》
2006年第6期509-512,共4页
Inner Mongolia Medical Journal
