摘要
目的对咪达唑仑靶控输注系统的准确性作出评价。方法20例ASAⅠ～Ⅱ级拟行下腹盆腔手术的女性患者,以椎管内麻醉复合靶控输注咪达唑仑镇静,设定咪达唑仑靶控血浆浓度为100ng/ml。监测血压、心率、脉搏血氧饱和度,并以BIS值作为咪达唑仑清醒镇静的药效学指标。从桡动脉取血样,以高效液相色谱法测定咪达唑仑血浆浓度。结果使用Burher药代动力学参数的咪达唑仑靶控输注系统用于我国女性患者偏离性(MDPE)为38.7%,精确度(MDAPE)为38.7%,摆动度为24.9%。结论Burher的咪达唑仑药代动力学参数于靶控输注系统应用需修正,方可准确用于我国女性患者椎管内麻醉清醒镇静。
Objective To evaluate the performance of the target controlled infusion （TCI） system with midazolarn during combined spinal and epidural anesthesia. Methods Twenty female patients scheduled for selective lower abdominal or pelvic surgery under combined spinal and epidural anesthesia were enrolled in this study. They use combined spinal and epidural anesthesia with tin-get controlled infusion of midazolam sedation. Midazolam plasma concentration was set at 100ng/ml. Blood pressure, heart rate, pulse oxygen saturation were monitored during anesthesia and operation. We use BIS as a pharmacodynamic value of midazolam sedation. Blood samples were taken from radial arterial far analysis of plasma midazolam concentration during infusion. Midazolam plasma concentration were lested by high performance liquid chromatography. Results MDPE of target controlled infusion with midazolam with Burher parameters was 38.7%, MDAPE was 38.7%, and wobble is 24.9% in Chinese female patients. Conclusions Burher parameters of midazolam target controlled infusion system should be correct, then can be used for our country female patients conscious sedation accurately.
出处
《医学研究杂志》
2006年第6期64-65,共2页
Journal of Medical Research
