摘要
背景:临床上评估炎症性肠病活动性的方法有临床活动度、C反应蛋白(CRP)和血沉等,三者常不一致。目的:探讨CRP评估炎症性肠病活动性的价值。方法:以Logistic回归法分析80例克罗恩病(CD)、70例溃疡性结肠炎(UC)患者血清CRP与血沉、临床活动度、内镜表现活动性、组织学活动性、低白蛋白血症、贫血、白细胞升高的关系;比较临床严重度、病变部位和药物治疗对CRP的影响。结果:CD中CRP与血沉相关;UC中CRP与血沉、外周血白细胞升高相关。CRP在活动性CD中显著升高(P<0.01),重度CD和结肠CD中CRP升高较其他各组明显(P<0.05);活动性UC中CRP亦显著升高(P<0.01),重度组中CRP升高较其他组明显(P<0.05)。药物有效控制临床表现时,CRP显著下降(P<0.01),复发时重新升高(P>0.05)。结论:CRP升高更适于反映中至重度结肠CD和UC的活动性;具有快速反映药物治疗有效性的特点。
Background： Clinical activity, C-reactive protein （CRP） and erythrocyte sedimentation rate are routinely used to evaluate the activity of inflammatory bowel diseases, but they are frequently in consistent. Aims： To appraise the role of CRP in evaluating activity of inflammatory bowel diseases. Methods： Logistic regression analysis was used to estimate the correlation of CRP with erythrocyte sedimentation rate, clinical activity, endoscopic activity, pathologic activity, hypoalbuminemia, anemia and peripheral white blood ceils count in 80 Crohn＇s disease （CD） and 70 ulcerative colitis （UC） patients. The effects of degree of disease severity, site of lesions and drug treatment on the illness were analyzed. Results： CRP elevation was associated with erythrocyte sedimentation rate in CD and erythrocyte sedimentation rate or peripheral white blood cells count in UC. CRP was significantly elevated in active CD and UC （P〈0.01）, especially in severe colonic CD and severe UC （P〈0.05）. CRP rapidly decreased when clinical activity was effectively controlled by drugs （P〈 0.01）, while re-elevated when the disease recurred （P〉0.05）. Conclusions： CRP elevation better reflects the activity of severe colonic CD and severe UC, but the decrease of CRP may indicate rapidly the effectiveness of drug treatment.
出处
《胃肠病学》
2006年第6期350-352,共3页
Chinese Journal of Gastroenterology
基金
上海市重点学科建设项目(No.Y0205)资助
