摘要
目的观察短小棒状杆菌（CP）治疗癌性胸水的疗效及不良反应。方法入选者均经过组织学和／或细胞学证实.采用胸腔闭式引流，排净胸水，随管注入CP7mg加生理盐水30ml，1次／周，末次注药4周判效。结果86例可评价疗效及不良反应.其中男59例，女27例，中位年龄54岁（28—80岁）。注药总184次，平均2．1次／例。完全缓解（CR）53例（61．6％），部分缓解（PR）29例（33．7％），总缓解率（RR）95．3％，稳定（SD）2例（2．3％），进展（PD）2例（2．3％）。Karnofsky评分提高20分以上者占45．4％（39／86），临床受益反应（CBR）改善者占50％（43／86）。Ⅰ-Ⅳ度不良反应主要是发热、胸痛、干咳。结论CP是目前临床上控制癌性胸水最为理想的方法。
Objective To evaluate the therapeutic effectiveness and adverse reactions in using treatment that infused the corynebacteria （CP） into the pleural cavity. Methods All the eligible patients have been confirmed by histological and/or cytological examination. Evacuate the hydrothorax of them adopting the closed drainage of pleural cavity, once a week, and infuse the CP 7mg mixed with physiological saline 30ml at the same time. Judge the curative effect in four weeks after the latest time infused CP to the patients. Results There are 86 cases can be evaluated in curative effect and adverse reaction. Among them,there are 59 male and 27 female. The medial age of them is 54 years old （28 years old to 80 years old）. The total times of treatments are 184, while 2. 1 times for each patients in average. The response in the 86 patients were 53 CR （61.6%） ,29PR（33.7% ） ,2SD（2. 3% ） and 2PD（2.3% ）. The overall response rate was 95.3%. It occupied 45.4% （39/86） whose Kamofsky Grade have been improve more than 20 scores. And the CBR improvers occupied 50% （43/86）. The nmin adverse reaction symptoms （Degree 1 to Degree 3 ）are fever,chest pain and dry cough. Conclusion The CP,at present,is the most effective medicine to control the brisket dissease cancer in clinical treatment.
出处
《中原医刊》
2006年第13期11-13,共3页
Central Plains Medical Journal
关键词
癌性胸水
短小棒状杆菌
胸腔闭式引流
Brisket disease cancer
Corynebacteriu
Thoracic cavity closed drainage
