摘要
采用二氧化硫(SO2)衍生物亚硫酸钠和亚硫酸氢钠(二者的物质的量之比为3:1)腹腔注射的方法,研究其对雄性小鼠生殖细胞的遗传毒性.结果表明,雄鼠经SO2衍生物染毒后再与雌鼠交配,导致:(1)雌鼠受孕率下降,显性致死率增高,且均有明确的剂量-效应关系;(2)胚胎生长迟缓,活胎平均重量下降.研究得出结论:SO2及其衍生物对雄性小鼠有生殖毒性作用.
Dominant lethal effect of sulfur dioxide （ SO2 ） derivatives on mice was studied when male mice were exposed to SO2 derivatives （ a mixture of sodium sulfite and sodium bisulfite, c ： c = 3 ： 1 ） by i. p. injection. The results showed that （ 1 ） the pregnant rate of female mice was decreased and the dominant lethal rate was increased in a dose-dependent manner when the male mice exposed to SO2 derivatives were made mating with female mice; （2） the embryonic development was retarded and the mean body weight of living fetus was decreased by the paternal mice exposed to SO2 derivatives in a dose-dependent manner. These results lead to a conclusion that SO2 and its derivatives had reproductive toxicity to male mice. Further study is needed to understand reoroductive toxicity of SO2 and its derivatives to human being. Tab 2, Ref 14
出处
《应用与环境生物学报》
CAS
CSCD
北大核心
2006年第3期360-362,共3页
Chinese Journal of Applied and Environmental Biology
基金
国家自然科学基金项目(No.30230310
No.20477023)资助~~
关键词
二氧化硫
亚硫酸钠
显性致死
生殖毒性
sulfur dioxide
sulfite
dominant lethal
reproductive toxicity
