摘要
为了探讨二氧化硫(SO2)的雄性生殖毒理效应,研究了SO2体内代谢衍生物———亚硫酸钠(Na2SO3)和亚硫酸氢钠(NaHSO3)混合液(物质的量比为3:1)对雄性昆明小鼠精子的毒性作用.采用腹腔注射(i.p.)染毒方法,每天注射一次,连续5 d,于染毒后d 35处死动物,观察和分析小鼠的精子活动度、数量和畸形率.结果表明:(1)SO2衍生物可引起小鼠精子数量尤其是正常活动度精子数量减少,引起不活动精子数量增加,且呈剂量-效应关系;(2)SO2衍生物可引起多种类型的精子畸形增加,尤其可引起不定形畸变精子的频率显著增加,总精子畸变率随染毒剂量的增加而呈剂量依赖性增高.由此推论,SO2污染有一定的雄性生殖毒性.
To investigate the reproductive toxicity effect of sulfur dioxide （ SO2 ） derivatives （ the mixture of sodium sulfite and sodium bisulfite, c ： c = 3 ： 1 ） , the damaging effect of SO2 derivatives on sperms of male Kunming mice was studied. Mice were continually injected through intraperitoneal route with SO2 derivatives once a day for 5 days. The mice were killed on d 35 after the first injection. Then the sperm activity, sperm quantity and sperm deformity of the mice were recorded and analyzed. The results showed： （ 1 ） SO2 derivatives caused a decrease in the sperm quantity and an increase in inactivity sperm quantity in a dose-dependent manner; （2） SO2 derivatives caused an increase in various types of sperm deformity, especially the increase in inconstant shapes of sperm deformity. In addition, SO2 derivatives led to an increase in percentage of sperms with deformity in a dose-dependent manner. These results suggested that SO2 pollution had reproductive toxicity effect on male creature, and more attention should be paid to the effect of SO2 pollution. Fig 1, Tab 2, Ref 14
出处
《应用与环境生物学报》
CAS
CSCD
北大核心
2006年第3期363-366,共4页
Chinese Journal of Applied and Environmental Biology
