摘要
目的:探讨肝硬化患者血清胰岛素样生长因子(IGF-Ⅰ)及其结合蛋白(IGFBP-3)检测的临床意义。方法:应用免疫放射分析测定35例肝硬化患者(肝硬化组),25例急性肝炎患者(肝炎组),35例健康人(对照组)血清IGF-Ⅰ、IGFBP-3水平,比较两者在3组中的浓度不同及在肝硬化不同Ch ild-Pugh级别者中的变化。结果:血清IGF-Ⅰ、IGFBP-3水平肝硬化组显著低于急性肝炎组和正常对照组(P<0.01),且在肝硬化组不同Ch ild-Pugh分级中呈逐渐下降。而急性肝炎组与正常对照组之间无显著差异(P>0.05)。结论:IGF-Ⅰ、IGFBP-3水平下降是发生肝硬化的重要指标之一。联合检测IGF-Ⅰ、IGFBP-3水平可用来综合评估肝硬化患者的肝功能状态。
Objective To investigate the clinical significance of the changes of serum IGF - Ⅰ and IGFBP - 3 levels in cirrhotic patients. Methods Serum IGF - Ⅰ and IGFBP - 3 levels were measured with IRMA in 35 patients with cirrhosis of liver, 25 patients with acute hepatitis and 35 controls. Results The serum IGF -Ⅰ and IGFBP- 3 levels in cirrhotic patients were significantly lower than those in patients with acute hepatitis and controls （P 〈 0.01 ）. Among the cirrhotic patients, the levels dropped steadily as the Childs＇ classification grade rose from Ⅰ to Ⅳ. There were no significant differences between the levels in patients with acute hepatitis and those in controls （P 〉 0.05）. Conclusion Decrease of serum IGF - Ⅰ and IGFBP - 3 levels was an important laboratory indicator of development of hepatic cirrhosis. Serum IGF - Ⅰ and IGFBP - 3 levels reflect the status of hepatic function well.
出处
《放射免疫学杂志》
CAS
2006年第3期172-173,共2页
Journal of Radioimmanology
