摘要
目的:通过动态观察G raves’病患者血清IFN-γ、IL-2及IL-6的含量变化,探讨细胞因子在G raves’病发病中的作用。方法:应用化学发光免疫分析测定血FT3、FT4、TSH含量,放射免疫分析测定IL-2、IL-6含量,双抗体夹心ELISA法测定IFN-γ含量,分析其与G raves’病的关系。结果:治疗前GD患者、GD复发者外周血IFN-γ、IL-6均高于正常对照组(P<0.01),IL-2低于对照组(P<0.01);缓解组外周血IL-6明显下降,IL-2明显升高,均接近正常对照组,IFN-γ含量虽然有所下降,但仍然明显高于对照组(P<0.01)。GD治疗前外周血IFN-γ、IL-6含量与FT3、FT4呈直线正相关,IL-2含量与FT3、FT4呈直线负相关。结论:细胞因子是认识G raves’病发病机理的重要线索,细胞因子与G raves’病的病程及病情控制密切相关,细胞因子对于估价G raves’病的病情、协助诊断及判断愈后有一定的指导意义。
Objective To investigate the possible role of cytokines （ IFN - γ, IL - 2, IL - 6） in the pathogenesis of Graves＇ disease. Methods Serum FT3, FT4, TSH （with CLIA）, IL -2, IL -6 （with RIA） and IFN -γ （with ELISA） contents were measured in the following subjects： （1） 42 patients with Graves＇ disease before any treatment, （2） 40 patients in remission after successful treatment with antithyroid drugs （ATD）, （3） 25 patients in relapse （around 6 months after cessation of two years＇ ATD treatment, （4） 40 controls. Results The serum IFN -γ and IL -6 contents in the patients before treatment and patients in relapse were signifi- cantly higher than those in the controls （P 〈0.01 ） while the IL -2 contents were significantly lower （P 〈0.01 ）. In patients in remission, the serum contents of IL - 2 and IL - 6 were not much different from those in the controls, but the serum IFN - γcontents, al- though dropped some- what, remained significantly higher than those in controls （P 〈 0.01 ）. The serum IFN -γ, IL- 6 contents were linearly positively correlated with the FT3 , FT4 levels while the serum IL - 2 contents were linearly negatively correlated with FT3, FT4, levels before treatment. Conclusion Contents of these cytokines fluctuated dynamically along with the status of Graves＇ disease and might be related to the pathogenesis in some way.
出处
《放射免疫学杂志》
CAS
2006年第3期183-185,共3页
Journal of Radioimmanology
