摘要
目的:研究不同浓度的羟基磷灰石(HAP)纳米粒子对小鼠H 22肿瘤细胞凋亡的影响。方法:以腹水瘤(H 22)小鼠为对象,观察对照组和高、中、低三个浓度的HAP纳米粒子与小鼠H 22肿瘤细胞凋亡的关系。结果:小鼠H 22肿瘤细胞对纳米羟基磷灰石(HAP)较敏感,能明显延长小鼠生存期(P<0.01),与丝裂霉素结果相近(P>0.05)。实验后小鼠体重没有明显下降。细胞的凋亡率随浓度升高而增大。结论:不同浓度的羟基磷灰石(HAP)纳米粒子能够诱导H 22肿瘤细胞的凋亡,并呈剂量依赖性。
Objective： To study the effect of HAP Nano-particles at its different concentrations on humor H22 apoptosis in mice. Methods： We divided the ascites tumor mice （H22） into three groups and the controlled group, then gave them different concentrations （ higher, moderate and lower） of HAP Nano -particles, and finally, compared them with each other to find out the relationship between the HAP Nano-particle concentrations and the apoptosis of H22 humor in mice. Results： Ascites tumor was apparently sensitive to Nano-HAP , and also prolonged the mouse life （P〈 0.01） ,nearly the same as the result of mitomycin （P 〈 0.05） . The mouse weight did not lower down after the experiment, and the apoptosis rate increased with increasing the Nano-HAP concentration. Conclusion： Nano-HAP at its different concentrations can induce the apoptosis of the humor H22 in mice, with a dosage dependence.
出处
《黑龙江医药科学》
2006年第3期14-15,共2页
Heilongjiang Medicine and Pharmacy
