摘要
目的:探讨妊娠期糖尿病(GDM)的易感性与HLA-DQA1基因多态性的关系。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测35例GDM患者(GDM组)及35例正常妊娠晚期妇女(对照组)的HLA-DQA1基因多态性频率。结果:GDM组孕妇与对照组孕妇相比较,HLA-DQA1*0201基因频率明显升高(22.86%vs11.43%),差异有显著性(P<0.05)。结论:HLA-DQA1*0201基因在天津及秦皇岛地区汉族GDM患者中频率较高,可作为GDM易感基因的候选基因,未发现GDM的保护基因。
Objective： To investigate the association between polymorphism of HLA-DQA1 and susceptibility of gestational diabetes mellitus （GDM）. Methods： This study enrolled 35 cases of GDM and 35 cases of normal pregnant women excluded diseases correlated with HLA gene. Polymerase chain reaction-Restriction fragment length polymorphism （PCR-RFLP） gene typing technique was used to detect HLA-DQA1 alleles. Results： It was observed that gene frequency of HLA-DQAl＊0201 increased in GDM group compared with control group （22.86%vs11.43%, P〈0.05,RR=2.84）. Conclusion： Gene frequency of HLA-DQAI＊0201 significantly increases in GDM at Han ethnic of China. It indicates that alleles HLA- DQAI＊0201 may be the susceptible gene of GDM. Which genotype acts as the protective gene is still unknown.
出处
《天津医科大学学报》
2006年第2期211-213,共3页
Journal of Tianjin Medical University
