摘要
目的观察乌司他丁(UT)对多脏器功能不全综合症(MODS)患者日间连续性血液滤过(CVVH)后炎症因子的影响。方法39例MODS患者随机分为治疗组(20例)和对照组(19例),除常规治疗外,治疗组于CVVH结束时予UT治疗,对照组予等量生理盐水治疗,观察两组的临床症状、APACHEⅡ评分,检测血清C反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)的变化。结果CVVH治疗可使APACHEⅡ评分、CRP、IL-6和TNF-α显著下降(P<0.001),停止CVVH后上述指标显著升高(P<0.05);于CVVH结束时应用UT可抑制上述指标上升。结论CVVH能很好地清除MODS的炎症因子,UT可抑制CVVH后炎症因子升高,两者联用可发挥协同作用。
Objective To investigate the effects of ulinastatin（UT） on plasma level of inflammatory mediators in patients with multiple organ dysfunction syndrome（MODS） after daytime continuous veno-venous hemofiltration （CVVH）. Methods Thirty-nine patients with MODS were randomly divided into group Ⅰ （n=20） and group Ⅱ （n=19）. Both groups were given routine treatment and daytime CVVH （12 h for once time, continued for 5 days）, while the patients of group I were given UT 1000ku at the end of CVVH. The clinic symptoms acute physiology and chronic health evaluation （APACHE Ⅱ ） were observed and serum levels of C-reactive protein （CRP）,interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α）were measured. Results CVVH can improve APACHE Ⅱ counts, reduce the serum levels of CRP, IL-6 and TNF-α significantly in both groups（P〈0. 001）,but they rebounded significatly after CVVH stopped in group Ⅱ （P〈 0.05）. UT,injected at the end of CVVH in group Ⅰ , can inhibit these rising. Conclusion CVVH could remove inflammatory mediators in patiens with MODS and UT could inhibit their rising when CVVH is topped,so they can cooperate in treatment.
出处
《江西医学院学报》
2006年第3期108-110,113,共4页
Acta Academiae Medicinae Jiangxi
关键词
连续性血液滤过
乌司他丁
C反应蛋白
自细胞介素
肿瘤坏死因子
continuous veno-venous hemofiltration
ulinastatin
C-reactive protein
interleukin
tumor necrosis factor
