摘要
目的研究缬沙坦对大鼠急性心肌梗死(AMI)后左室重塑的影响。方法将冠脉结扎术后24 h的SD大鼠随机分为心梗组、缬沙坦小剂量组(10 mg·kg-1·d-1)和缬沙坦大剂量组 (30 mg·kg-1·d-1)组,另设假手术组。灌胃给药四周后测定以下指标:(1)左心功能;(2)体重 (BW)、左心室重量(LVM)及左室重量指数(LVMI);(3)心肌梗死面积;(4)左室非梗死区胶原容积分数(CVF。)。结果各心梗组间的心肌梗死面积无显著差别(P>0．05)。与假手术组相比,心梗组左室舒张末压(LVEDP)、INM、LVMI及CVF明显增大,左室收缩压(LVSP)和心室内压最大变化速率 (±dp／dtmax)明显降低(P均<0．01)。与心梗组相比,大剂量缬沙坦可使LVEDP明显降低,±dp／ dtmax明显升高(P<0．01),小剂量缬沙坦对心梗大鼠心功能影响不明显。两种剂量缬沙坦都可明显降低心梗大鼠LVM、LVMI及左室非梗死区CVF,且大剂量缬沙坦较小剂量更显著。结论缬沙坦能够抑制大鼠AMI后的左室肥厚及非梗死区胶原沉积,改善AMI后的左室重塑。
Objective To study the effects of valsartan on left ventricular remodeling after acute myocardial infartion in rats. Methods Twenty-four hours after the operations of ligation on the coronary arteries, the surviving SD rats were randomly divided into 3 groups： AMI group, low-dose valsartan treatment group（ 10mg·kg^-1·d^-1 ） and high-dose valsartan treatment group（30mg·kg^-1·d^-1 ）. The sham-operated group was also estabished. After four weeks of treatment, the following items were measured： （1） the function of left ventricle; （2） body weight（BW） ,left ventricaular mass （LVM） and LVMI（ left ventricular mass index）;（3）the infarct size of the heart; （4）The collagen volume fraction （CVF） of the noninfarct zone in left ventricle（LVNIZ）. Results There was no significant difference in the infarct size of the heart among the AMI groups（P 〉 0.05）. Compared with the sham-operated group, LVEDP,LVM,LVMI,CVF of AMI group increased significantly（P all 〈 0.01 ）while LVSP and ± dp/dtmax decreased significantly（ P〈0.01）. High-dose valsartan decreased LVEDP and increased ± dp/ dtmax of AMI group（ P 〈 0.01 ） while low-dose valsartan had no significant effect on the function of left ventricle in AMI group. Both high and low dose valsartan decreased LVM,LVMI,CVF of AMI group significantly（P all 〈 0.01 ）and the high dose valsartan had a more significant effect than the low dose（P 〈 0.01 ）. Conclusion Valsartan can limit myo- cardial hyper trophy, attenuate the development of myocardial interstitial fibrosis in the noninfarcted left ventricle and so improve left ventricular remodeling after acute myocardial infartion in rats.
出处
《中国分子心脏病学杂志》
CAS
2006年第3期145-148,共4页
Molecular Cardiology of China
关键词
缬沙坦
大鼠
心肌梗死
左室重塑
Valsartan
Rats
Myocardial infarction
Left ventricular remodeling
