摘要
目的观察国产唑来膦酸(博来宁)治疗恶性肿瘤骨转移的临床疗效和不良反应。方法国产唑来膦酸4mg加入0.9%氯化钠溶液100ml中静脉滴注15分钟。每4周重复给药1次,3次后评价疗效。结果止痛有效率为79.2%,维持中位时间25天。活动能力改善有效率为66.7%。结论国产唑来膦酸可缓解恶性肿瘤骨转移所致疼痛,改善生活质量,且不良反应轻微,耐受性好。
Objective：To evaluate clinical efficacy and toxicity of zoledronic acid in the treatment of the bone metastases in patients with malignancy. Methods： Twenty four patients with bone metastatic cancer were treated with zoledronic acid 4mg by intravenous infusion for 15 minutes. The treatment was repeated every 28 days, up to 3 times. Results ：The response rate of bone pain relief was 79.2%. The median maintain time was 25 days. The response rate of activity improvement was 66.7%. Conclusion： Zoledronic acid can relieve bone pain and improve quality of life in patients with metastatic cancer of bone. The toxicity was mild and well tolerated.
出处
《现代肿瘤医学》
CAS
2006年第7期889-890,共2页
Journal of Modern Oncology
关键词
唑来膦酸
骨转移癌
疼痛
zoledronic acid
bone metastatic cancer
pain
