摘要
对２８例慢性肝炎、２３例肝炎性肝硬化及２６例原发性肝癌患者血清中ＩＬ－１、ＩＬ－８及ＴＮＦα活性进行了测定。结果表明，慢性肝炎患者ＩＬ－１、ＩＬ－８及ＴＮＦα活性分别为１５３８．３±３８６．５ｐｇ／ｍｌ，５０６．５±１３１．３ｐｇ／ｍｌ及２１２．６±９８．４ｐｇ／ｍｌ，明显高于对照组（Ｐ＜０．０１）；肝炎性肝硬化患者ＩＬ－１、ＩＬ－８及ＴＮＦα活性分别为２１６２．８±４３６．６ｐｇ／ｍｌ，６８２．６±２０４．５ｐｇ／ｍｌ及２４１．５±１０９．６ｐｇ／ｍｌ，明显高于对照组（Ｐ＜０．０１）；原发性肝癌患者ＩＬ－１、ＩＬ－８活性分别为６３２．６±１０７．６ｐｇ／ｍｌ，３１２．８±９５．８ｐｇ／ｍｌ，与对照组比较，ＩＬ－１活性明显升高（Ｐ＜０．０５），ＩＬ－８活性程度升高，但无明显差异（Ｐ＞０．０５）ＴＮＦα活性为３２１．６±１８３．２ｐｇ／ｍｌ，明显高于对照组。亦对上述３种细胞因子与慢性肝炎、肝硬化发生发展关系进行了初步分析与探讨。
The activity of interleukinl(IL-1), interleukin8(IL-8)and tumor necrosis factor-alpha in the sera from patients with chronic hepatitis(CH),hepatocirrhosis(HC) and hepatocellular carcinoma (HCC)was detected. The results indicated that IL-1, IL-8 and TNF in sera from patients with CH was 1538.3±386.5, 506. 5±131.3 and 212.6 ± 98.4 pg/ml respectively which were significantly higher than those of normal controls; that IL-1, IL-8 and TNF activity in sera from patients with HC was 2162.8±431.6, 682.6±204.5, 241.5± 109.6 pg/ml respectively, which were significantly higher than those of normal controls and that IL-1, IL-8 and TNF activity in sera from patients with HCC was 632.6±107.6, 312.8 ±95. 8 and 321.6±183. 2 pg/ml respectively, TNF and IL-1 activities were significantly higher than those of normal controls. The relationship among IL-1, IL-8 and TNF activity with immuno-damage of CH and fibroproliferation of liver disease was also investigated.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1996年第4期257-258,共2页
Chinese Journal of Immunology
关键词
肝炎
肝硬化
细胞因子
肝肿瘤
TNFΑ
IL
Chronic hepatitis Hepatocirrhosis Hepatocellular carcinoma Cellular factor
