摘要
分别以羧甲基纤维素和淀粉为壁材,利用冷冻干燥法在不同的工艺条件下制备得到恩诺沙星微胶囊制剂。缓释试验表明:以羧甲基纤维素和淀粉为壁材的恩诺沙星微胶囊均表现出明显的缓释作用,且羧甲基纤维素的缓释性能优于淀粉,冷冻温度的降低能促进微胶囊缓释性能。其中,恩诺沙星原料药在4.5 min时的溶出率达到99.4%。-40℃和-50℃条件下制备的以羧甲基纤维素为壁材的恩诺沙星微胶囊在14 h的溶出率分别为99.2%和99.7%;-40℃和-50℃条件下制备的以淀粉为壁材的恩诺沙星微胶囊在12 h的溶出率为99.4%和99.6%。
Enveloped by cellulose CM and starch, the enrofloxacin microencapsulations were prepared by freezingdry respectively. The results of controlled-release tests implied that the enrofloxacin microencapsulation enveloped by both cellulose CM and starch have showed the distinct controlled-release properties. The controlled-release properties of cellulose CM are superior to those of starch. The lower freezing temperature can improve the controlledrelease properties. While the releasing percentage of the enrofloxacin raw material reached 99.4% after 4.5 min, the ones of the enrofloxacin microencapsulation enveloped by cellulose CM at -40℃ and -50℃ reached 99.2% and 99.7% respectively. The ones of the enrofloxacin microencapsulation enveloped by starch at - 40℃ and -50℃ reached 99.4% and 99.6% respectively.
出处
《上海水产大学学报》
CSCD
北大核心
2006年第3期375-379,共5页
Journal of Shanghai Fisheries University
基金
上海市教委青年基金项目(03-129)
上海市教育委员会E-研究院建设项目(E03009)
上海市重点学科建设项目(Y1101)资助
关键词
冷冻干燥
恩诺沙星
微胶囊
缓释
freezing-dry
enrofloxacin
microencapsulation
controlled-release
