摘要
目的观察经尿道选择性绿激光前列腺汽化术(PVP)治疗前列腺增生症(BPH)患者,血清中的总前列腺特异性抗原(T-PSA)、游离PSA(F-PSA)水平和总/游离(F/T)PSA比值的变化,探讨其在PVP术后随访中的意义。方法对120例BPH患者行PVP治疗,采用化学发光免疫法分别检测术前1h、术后24h和1个月患者血清中的总PSA和游离PSA水平,并计算游离/总PSA比值,随访比较分析手术前后PSA变化差异。结果术后24h患者血清总PSA值平均为(15．5±8．4)μg/L及游离PSA值平均为(2．8±1．2)μg/L,均明显高于术前患者血清总PSA值(4．2±1．5)μg/L及游离PSA值(0．8±0．3)μg/L,差异有统计学意义(P＜0．05)。血清游离/总PSA比值术前术后比较差异无统计学意义(P＞0．05)。术后1个月血清总PSA值、游离PSA值及游离/总PSA比值与术前比较差异无统计学意义(P＞0．05)。结论与血清中的总PSA和游离PSA水平相比,血清游离/总PSA比值是PVP术后短期及长期随访的一个更可靠指标。
Objective To investigate the effect of the photoselective vaporization prostatectomy （PVP） on serum total prostate-specific antigen （PSA）, free PSA levels and free to total PSA ratio in patients with benign prostatic hyperplasia （BPH） and to predict the level of clinical efficacyof PVP for treating obstructive benign prostatic hyperplasia （BPH） . Methods The PVP with an average of 80 W of KTP laser energy was used for 120 patients diagnosed with obstructive lower urinary tract symptoms secondary to BPH. Serum total PSA and free PSA levels were determined 1 h before and 24 h, 1 month after PVP therapy by using chemiluminescence methods. Preoperative and postoperative free and total PSA and free to total PSA ratio were statistically compared. Results The postoperative serum total PSA （ 15.5±8.4） μg/L and free PSA （2.8 ± 1.2） μg/L were increased significantly as compared with preoperative total PSA （4.2 ± 1.5） μg/L and free PSA （0.8±0.3） μg/L levels, respectively （ P〈0.05）. The difference between preoperative and postoperative free to total PSA ratio was not statistically significant （P〉0.05）. The postoperative 1-month serum total PSA and free PSA and free to total PSA ratios were not statistically significant, respectively （P〉0.05）. Conclusion Compared with the postoperative serum total PSA and free PSA, the postoperative serum free to total PSA ratio may be a more reliable parameter during the follow-up after PVP.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2006年第7期862-863,共2页
Chinese Journal of Experimental Surgery
基金
全军"十一五"计划资助项目(06MA297)
