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宫颈癌组织中人乳头瘤病毒以及单纯疱疹病毒感染的检测 被引量：3

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摘要 目的研究人乳头瘤病毒(HPV)以及单纯疱疹病毒(HSV)以及HPV各型别在宫颈癌变中的作用。方法采用PCR方法对宫颈癌和正常宫颈组织HPV、HSV的DNA进行检测,并应用限制性内切酶片段长度多态性方法对HPVDNA进行分型。结果宫颈癌标本HPV的检出率为58.33%,正常宫颈组织标本HPV检出率10.71%。宫颈癌组织中检测到的HPV型别以HPV16、HPV18为主。宫颈癌组织标本中HSV检出率28.33%,正常宫颈组织标本7.14%。宫颈癌组织标本中,HSV与HPV感染可能有相关性。结论HPV感染与宫颈癌变有密切关系,以HPV16和HPV18为主。HSV可能作为HPV协同因子在宫颈癌变过程中发挥作用。
作者 阮建波 康东平 吴秋良
机构地区 广东省东莞市太平人民医院 中山大学肿瘤医院
出处 《中国中西医结合皮肤性病学杂志》 CAS 2006年第2期93-94,共2页 Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
关键词 人乳头瘤病毒 单纯疱疹病毒 子宫颈癌
分类号 R752 [医药卫生—皮肤病学与性病学]
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参考文献10

  • 1[1]Smith JS,Herreo R,Bosetti C,et al.Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer[J].J Natl Cancer Inst,2002,94(21):1604-1613.
  • 2蔓小红,王家璧,刘跃华,马东来,刘方,左亚刚.某些外生殖器表皮肿瘤皮损中HPVDNA的检测和分型[J].中华皮肤科杂志,2004,37(5):280-282. 被引量：6
  • 3吴玉萍,张颖,李文典,郭裕萍,汪亚平.乳头瘤病毒及协同因子与宫颈癌的关系[J].遗传,2002,24(2):121-124. 被引量：1
  • 4[4]Bernard HU,Chan SY,Manos MM,et al.Identification and assessment known and novel human papillomavirus by polymerase chain reaction amplification,restriction fragment lenth polymorphism,neucleotide sequence,and polygenetic algorithm[J].J Infect Dis,1994,170(5):1077-1085.
  • 5[5]Koutsky L.Epidemiology of gental human papillomavirus infection[J].Am J Med,1997,102(5A):3-8.
  • 6王彤,李亚里.人乳头瘤病毒与宫颈癌[J].解放军医学杂志,2005,30(1):79-81. 被引量：11
  • 7[7]Baay MFD,Quint WGV,Koudstaal J,et al.Comprehensive study of several genital and type specific primer pairs for detection of human papillomavirus DNA by PCR in paraffin embedded cervical carcinoma[J].J Clin Microbiol,1996,34(3):745-747.
  • 8郑曙民,孙立新,武燕,岳丽萍,黄慧,石利香,付静波.宫颈癌与性传播因子的探讨[J].肿瘤研究与临床,2000,12(1):21-22. 被引量：12
  • 9[9]Pisani S,Imperi M,Seganti L,et al.Effect of HSV-2 infection on the expression of HPV 16 genes in CaSki cells[J].Int J Immunopathol Pharmacol,2004,17 (1):65-70.
  • 10[10]DiPaolo JA,Woodworth CD,Coutlee F,et al.Relationship of stable integration of herpes simplex virus-2 Bg/Ⅱ N subfragrment Xho2 to malignant transformation of human papillomavirus immortalized cervical keratinocytes[J].Int J Cancer,1998,76(6):865-871.

二级参考文献37

  • 1Parkin DM, Pisani P, Ferlay J. Global cancer stastiatics. CA Cancer J Clin, 1999,49:31.
  • 2Munoz N, Bosch FX, Sanjose S et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med,2003,348..518.
  • 3Malano M, Posso H, Weiderpass E et al. Prevalence and determinants of HPV infection among Colombian women with normal cytology. Br J Cancer, 2002,87:324.
  • 4Petry KU, Menton S, Monton G et al. Inclusion of HPV testing in routing cervical cancer screening for women above 29 years in Germany: result for 8466 patient. Br J Cancer, 2003,88:1570.
  • 5Savre EI, Kjaer SK, Worm AM etal. Risk factors for genital HPV DNA in men resemble those found in women: a study of male attendees at a Danish STD clinic. Sex Transm Infect, 2002,78:215.
  • 6Walboomers JM, Jacobs MV, Bosch FX et al. Human papillomarvirus is a necessary cause of invasive cervical cancer worldwide. J Pathol, 1999,189:12.
  • 7Branca M, Garbuglia AR, Benedetto A et al. Factors predicting the persistence of genital human papillomavirus infections and PAP smear abnormality in HIV-positive and HIV-negative women during prospective follow up. Int J STD AIDS,2003,14:417.
  • 8Kwasniewska A, Tukendorf A, Gozdzicka A et al. Content of folic acid and free homocysteine in blood serum of human papillomaviru-infected women with cervical dysplasia. Eur J Gynaecol Oncol, 2002,23 : 311.
  • 9Pillai MR, Chaclo P, Kesari LA et al. Expression of folate receptors and heterogeneous nuclear ribonucleoprotein Elin women with human papillomavirus mediated transformation of cervical tissue to cancer. J Clin Pathol,2003,56:569.
  • 10Ziegler G, Weinstein SJ, Fears R et al. Nulrilinal and genetic inefficiencies in one-carbon metabolism and cervical cancr risk. J Nutr,2002,132:2345.

共引文献26

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二级引证文献17

中国中西医结合皮肤性病学杂志
2006年 第2期

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