摘要
围绕学习、记忆、情绪及应激等心理因素与复发的关系,应用阿片类物质心理依赖研究条件性位置偏爱,条件性位置厌恶,Morris水迷宫量化觅药动机模型,行为及条件性行为敏感化等多种动物行为模型,从情绪相关学习、记忆在成瘾行为中的作用,不同神经核团与神经递质系统活动性的改变,应激相关因素易化的成瘾易感性,自然奖赏与成瘾药物奖赏相关记忆的比较研究等方面,对应激与记忆相关的吗啡心理依赖及复发的脑机制进行了系列研究。
This project focuses on investigations of the brain mechanisms of the psychological dependence of abusive drugs. By using various animal models, such as conditioned place preference （CPP）, conditioned place aversion （CPA）, drug-seeking intensity gradation model of Morris water maze, behavioral and conditioned behavioral sensitization, the roles of environmental stress, positive and negative emotional states on psychological dependence and its relapse, neural mechanism comparisons between drug reward and natural reward were explored from behavioral to neuronal and genetic level.
出处
《心理科学进展》
CSSCI
CSCD
北大核心
2006年第4期522-531,共10页
Advances in Psychological Science
基金
国家重点基础研究发展计划(2003CB515404)
国家自然科学基金(30230130
30470578)资助项目。
关键词
学习记忆
应激
心理依赖
成瘾易感性
觅药动机
自然奖赏
Learning, Memory
Stress
Psychological dependence
Individual differences
Drug seeking
Natural reward
