摘要
[目的] 分析1991-2004年广东省乙型流感病毒抗原变异和流行情况. [方法] 用9～11日龄鸡胚和（或）MDCK细胞分离流感病毒,病毒鉴定用常量红细胞凝集抑制法（HI）;人血清流感抗体检测用微量半加敏红细胞凝集抑制法.[结果] 广东省一直有乙型流感流行,并从人群中分离到流感病毒2 916株,乙型流感病毒占23.3%.乙型流感病毒两大谱系交替为优势株,除1994、1997及2002年以Victoria系为主外,其余各年以Yamagata系为主.乙型流感病毒抗原性不断发生漂移,历年一般人群血清乙型流感抗体检测阳性率在 28.3%～73.9%.[结论] 1991-2004年广东省乙型流感病毒存在差异较大的两个谱系,病毒谱系的轮换和抗原漂移导致乙型流感不断流行.
[Objective] To analyze the activity status, antigenic drift and epidemiological characteristics of influenza B in Guangdong, China for the disease control （1991-2004）. [Methods] Influenzas B viruses were isolated or recovered by embryonated eggs aged 9-11 days and/or MDCK cells, and the viruses were identified by hemagglutination inhibition （HI） method. The serum antibody was detected by micro HI. [Results] There were influenza B virus epidemic in Guangdong during these years. 2 916 strains were isolated and 23.3% of them were influenza B. Two predominant lineages of influenza B virus co-circulated in Guangdong. The main lineage was Yamagata, hut Victoria was more active in 1994, 1997 and 2002. Antigenic drift occurred there continuously. The positive rate of anti-B antibody were ranged from 28. 3% to 73. 9% in general population. [Conclusion] During 1991-2004, two major lineages of influenza B circulated in Guangdong. The alternation of two lineages and antigenic drift continuously resulted in influenza B epidemic.
出处
《海峡预防医学杂志》
CAS
2006年第3期12-14,共3页
Strait Journal of Preventive Medicine
基金
广东省医学科研基金(项目编号:A2004080)
关键词
乙型流感病毒
抗体监测
抗原分析
疾病控制
Influenza B Virus
Surveillance Antibody
Antigenic Analysis
Disease Control
