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血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂在缺血性卒中中的应用与前景 被引量：8

The Application and Prospect of Platelet Glycoprotein ⅡbⅢa Receptor Antagonist in Ischemic Stroke
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摘要 血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂是一类新型抗血小板药。文章从血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂与溶栓药联合应用、在颈动脉血管成形和支架置入术中的应用以及单独使用等方面探讨了其在缺血性卒中中的应用与前景。 Platelet glycoprotein Ⅱb/Ⅲa receptor antagonists is a class of novel antiplatelet agents, This article explores the application and prospect of platelet glycoprotein Ⅱb/Ⅲa receptor antagonists in ischemic stroke from the aspects of its combination with thrombolytic agents, the application of carotid artery angioplasty and stenting （CAS）, and be used alone.
作者 叶妮 张临洪
机构地区 武汉市中心医院神经内科
出处 《国际脑血管病杂志》 2006年第6期432-436,共5页 International Journal of Cerebrovascular Diseases
关键词 血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂 缺血性卒中 溶栓 颈动脉血管成形术 支架置入术 platelet glycoprotein Ⅱb/Ⅲa receptor antagonists ischemic stroke thrombolysis carotid artery angioplasty stenting
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献34

  • 1Braunwald E,Antman EM,Beasley JW,et al.ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction-summary article:a report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee on the Management of Patients With Unstable Angina).J Am Coll Cardiol,2002,40:1366-1374.
  • 2Monagle P,Chan A,Massicotte P,et al.Antithrombotic therapy in children:the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.Chest,2004,126(Suppl 3):645S-687S.
  • 3Mousa SA.Antiplatelet therapies:from aspirin to GP Ⅱb/Ⅲa-receptor antagonists and beyond.Drug Discov Today,1999,4:522 -561.
  • 4Jennings LK,Jacoski MV,White MM.The pharmcodynamics of parenteral glycoprotein Ⅱb/Ⅲa inhibitors.J Interv Cardiol,2002,15:45 -60.
  • 5Tcheng JE. Clinical challenges of platelet gtycoprotein Ⅱb/Ⅲa receptor inhibitor therapy: bleeding, reversal, thrombocytopenia, and retreatment.Am Heart J, 2000, 139:S38 - S45.
  • 6Lapchak PA, Araujo DM. Therapeutic Potential of Platelet Glycoprotein Ⅱb/Ⅲa Receptor Antagonists in the Management of Ischemic Stroke. Am J Cardiovasc Drugs, 2003, 3:87 -94.
  • 7Seitz R J,Hanzavi M,Junghans U,et al.Thrombolysis with recombinant tissue plasminogen actiwtor and tirofiban in stroke:preliminary obserrations.Stroke,2003,34:1932-1935.
  • 8Seitz RJ,Meisel S,Moll M,et al.Partial rescue of the perfusion deficit area by thrombolysis.J Magn Reson Imaging,2005,22:199-205.
  • 9Straub S,Junghans U,Jovaaovic V,et al.Systemic thrombolysis with recombinant tissue plasminogen activator and tirofiban in acute middle cerebral artery occlusion.Stroke,2004,35:705 -709.
  • 10Mangiafico S,Cellerini M,Nencini P,et al.Intravenous glycoprotein Ⅱ b/Ⅲa inhibitor (tirofiban) followed by intra-arterial urokinase and mechaaical thrombolysis in stroke.AJNR Am J Neuroradiol,2005,26:2595-2601.

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国际脑血管病杂志
2006年 第6期

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