期刊文献+

Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits 被引量:1

Synthesis of Pyridyl Polyheterocyclic Oxime-ether Schiff Bases Containing s-Triazole and Oxadiazole Subunits
下载PDF
导出
摘要 4-Amino-5-pyridin-4-yl-s-triazole-3-thiol (1) was sequentally reacted with 3-chloro-1- phenylpropan-1-one to afford 3-(4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl)-1-phenylpropan-1- one (2) followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-cbloromethanes to the corresponding oxime (3) and oxime-ethers (4a-e), respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds (5a-e). The antibacterial activity in vitro against Gram-postive (G^+) and Gram negative (G) bacteria was primarily evaluated. 4-Amino-5-pyridin-4-yl-s-triazole-3-thiol (1) was sequentally reacted with 3-chloro-1- phenylpropan-1-one to afford 3-(4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl)-1-phenylpropan-1- one (2) followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-cbloromethanes to the corresponding oxime (3) and oxime-ethers (4a-e), respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds (5a-e). The antibacterial activity in vitro against Gram-postive (G^+) and Gram negative (G) bacteria was primarily evaluated.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2006年第7期899-902,共4页 中国化学快报(英文版)
基金 the State Basic Research and Development Project (No. G 1998051112) the Science Foundation of Henan University (04ZDZR009).
关键词 Pyridine triazole OXADIAZOLE oxime-ether schiff base antibacterial activity. Pyridine, triazole, oxadiazole, oxime-ether, schiff base, antibacterial activity.
  • 相关文献

同被引文献3

引证文献1

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部