摘要
本文对２５例地高辛中毒的难治性心衰病人进行监测，结果显示有１５例病人表现出不同程度的中毒症状，平均血药浓度为２．９３ｎｇ／ｍｌ；１０例无明显临床中毒表现，平均血药浓度为２．１９ｎｇ／ｍｌ。地高辛临床药动学参数较一般心衰病人有非常显著性差异（Ｐ＜０．０１），Ｔ＿（１／２），延长４４．１％，Ｖｄ减少１６％，ＣＬ减少４０．８％，ＣｒＣＬ减少２４．８％。在地高辛中毒的诸多诱因中，以肾功能和年龄影响最为显著，ＣｒＣｌ和ＣＬ，Ｖｄ存在良好的正相关，年龄和Ｖｄ存在极好的负相关（Ｐ＜０．０１）。
he monitoring of 25 toxic patients given digoxin with therapyresistant congestive heart failure was studied.The result showed there were 15 patients with toxic symptoms in different degree, the blood concentration ofdigoxin was 2. 93ng/ml. The concentration of 10 patients without signal clinical toxic symptoms was 2. 19ng/ml.There was a signal differece between their clinical pharmacokinetic parameters and cornmon patients. with heartfailure (P<0. 01) , 44. 1 % of T1/2 was longthened,1 6% of Vd , 40.8% of CL and 24. 8% of CrCL decreased. The ef-fect of ronal function and age appeared the signalest for many digoxin toxic factors. There was a good positive cor-relation between CrCL and CL ,Vd ,an excellent negative correlation between age and Vd (P<0.0l ) . This showedthat slight impariment of ronal function could cause decrease of CL in a comparative great degree and variation ofVd. With age became old ,variation of body's tissue causing decrease of Vd,which all make T1/2 of digoxin long andblood concentration of digoxin high.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1996年第7期295-297,共3页
Chinese Journal of Hospital Pharmacy
关键词
心力衰竭
药物疗法
地高辛
血药浓度
中毒
监测
refractory congestive heart failure,digoxin, blood concentration of drug, clinical pharma-cokinetics, dosage regimen
