摘要
采用苯基荧光酮分光光度法测定了６例健康人单剂口服２０ｍｇ／ｋｇα－羧乙基锗倍半氧化物后血清药浓度，人体内药物动力学过程符合单室模型，主要参数Ｋ０．３２１ｈ－１，Ｋａ１．２２１ｈ－１，Ｔ１／２２．１６１ｈ，Ｔｍａｘ１．８８５ｈ，Ｃｍａｘ１２．７６１μｇ／ｍｌ。
he serum concentration of 2 carboxyethylgermanium sesquioxide in six healthy volunteers each received 20mg/kg by one singledose oral administration was determined by phenlyfluorone spectrophotometric method. The results indicated that recovery was 101.1% with better liner relation ( r = 0.9998 ), the kinetics of this drug fit a onecompartment model, the main pharmacokinetic parameters were K 0.321 h -1 , Ka 1.221 h -1 , T 1/2 2.161 h, T max 1.885 h and C max 12.761 μg/ml.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1996年第8期344-346,共3页
Chinese Journal of Hospital Pharmacy
关键词
锗-132
药物动力学
carboxyethylgermanium sesquioxide, pharmacokinetics, phenlyfluorone spectrophotometric method
