摘要
目的：以丙烯酸树脂Ⅱ为主要材料，研究雷公藤双层片制备工艺。方法：分别对双层片速释部分、缓释部分进行辅料筛选，通过正交设计试验，以体外溶出度测定优化处方和工艺。结果：处方优选为速释部分：雷公藤浸膏15g，淀粉适量，碳酸钙10g：缓释部分：雷公藤浸膏35g，PEG600017．5g，糊精52．5g，丙烯酸树脂Ⅱ10．5g。雷公藤双层片在2，5，10h药物释放分别达到20％-40％，40％-65％，75％以上。结论：本处方合理、工艺可行，适于雷公藤双层片的制备，产品缓释性能良好。
OBJECTIVE To study the preparation procedure of the Radix Tripterygjun wilfordii double-deck tables using eudragit L Ⅱ as the main material. METHODS The orthogonal design was applied to optimize the prescription and preparation formulation with respect to the release rate by selecting the excipients of rapid-release part and slow-release part. RESULTS The selected formulation was that is the rapid -release part： the Radix Tripterygjun wilfordii extraction 15 g; CaCO3 10 g and proper amourt of starch. The slow-release part： the Radix Tripterygjun wilfordii extraction 35 g, PEG6000 17. 5 g, dextrin 52. 5 g, eudragit L Ⅱ 10.5 g. The sustained -release property of Radix Tripterygjun wilfordii double-deck tablets was good. The drug release rate can reach 20% -40% at 2 hours; 40% -60%, 5 h; above 75%, 10 h. CONCLUSION The fromulation and processing procedure are suitable for preparing the tablets, the sustained release property of the tablets is good.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2006年第7期812-814,共3页
Chinese Journal of Hospital Pharmacy
关键词
雷公藤
双层片
制备工艺
正交设计
radix tripterygjun wilfordii
double-deck tablets
preparation technology
orthogonal design
