摘要
瞄准：比较有标准 7-d 的四倍的治疗增加两倍的一天为在中国的一张农村人口的 H pylori 根除的治疗。方法：396 个病人与的一个总数(13 ) pylori 被分配进二的为 H 阳性的 C 脲呼吸测试组织：239 个病人收到了一天四倍的治疗(amoxicillin 2000 mg qid；灭滴灵 500 mg qid；枸橼酸铋 900 mg qid 和 lansoprazole 60 mg 从前每日) 并且 157 个病人收到了 7-d 标准三元组治疗(amoxicillin 1000 mg 出价；clarithromycin 500 mg 出价和 lansoprazole 30 mg 出价) 。所有病人经历了一(13 ) 六个星期估计 H pylori 感染的根除的 C-UBT 术后疗法。结果：229 个病人完成了一天治疗(95.8%) ， 148 个病人完成了 7-d 治疗(94.2%) 。一天治疗根除了在 64 个病人(27.95%) 的 H pylori 感染。相反， 103 个病人(69.59%) 是在 7-d 治疗以后否定的 H pylori (P 【
0.01 ) 。结论：这个预研项目建议与 7-d 标准治疗相比没有在 H pylori 感染的治疗的一天治疗的有益的效果。
AIM： To compare the one-day quadruple therapy with a standard 7-d triple therapy for H pylori eradication in a rural population of China. METHODS： A total of 396 patients with 13C-urea breath test positive for H pylori were assigned into two groups： 239 patients received one-day quadruple therapy （amoxicillin 2000 mg qid; metronidazole 500 mg qid; bismuth citrate 900 mg qid and lansoprazole 60 mg once daily） and 157 patients received 7-d standard triple therapy （amoxicillin 1000 mg bid; clarithromycin 500 mg bid and lansoprazole 30 mg bid）. All the patients underwent a 13C-UBT to assess the eradication of Hpylori infection six weeks after treatment. RESULTS： Two hundred and twenty-nine patients completed the one-day therapy （95.8%） and 148 patients completed the 7-d therapy （94.2%）. The oneday therapy eradicated H pylori infection in 64 patients （27.95%）. In contrast, 103 patients （69.59%） were Hpylori negative after the 7-d therapy （P 〈 0.01）. CONCLUSION： This pilot study suggests there is no beneficial effect of the one-day therapy in treatment ofHpylori infection compared with the 7-d standard therapy.
基金
Supported by a grant from International Digestive Cancer Alliance and Peking University School of Oncology
关键词
幽门螺杆菌
农村
细菌感染
治疗方法
Eradication
H pylori infection
Quadrupletherapy
Triple therapy
