摘要
目的探讨发生原发性高血压、冠心病与血管紧张素Ⅱ1型受体基因(AT1R)多态性与社区汉族人原发性高血压和冠心病的相互关系。方法用PCR技术检测AT1R基因3’端非翻译区(3’-UTR)A1166C多态性。并对100例健康体检者2、03例原发性高血压(EH)患者1、58例原发性高血压合并冠心病患者的AT1R基因A1166C多态性进行分析;用生化技术测定血脂水平。结果高血压患者中无论是否合并冠心病,其AT1R A1166C基因型分布均与对照组无显著性差异(P>0.05)。高血压合并冠心病组与无冠心病组之间的AT1R基因型分布亦无显著差异(P>0.05)。结论AT1R基因A1166C多态性与中国人高血压病发生及高血压患者是否易患冠心病无关。
Objective To explore the relationship between angiotensin Ⅱ type 1 receptor （ATIR） gene polymorphism and essential hypertension （EH） complicated with coronary artery disease （CHD）. Methods Angiotensin II type 1 receptor genotypes were investigated with PCR in 203 hypertensive patients, 158 patients complicated with CHD and 100 healthy people. Results The distribution of ATIR genotypes was of no significant difference between hypertension patients and health controls （ P 〉 0.05 ）. No significant differences in genotype frequencies of ATIR gene were found between EH complicated with CHD and those without CHD （ P 〉 0.05）. Conclusion There is no relationship between AT1R A1166C polymorphism and hypertension. AT1R genotypes do not significantly influence the incidence of CHD in the hypertension.
出处
《河南科技大学学报（医学版）》
2006年第2期86-88,共3页
Journal of Henan University of Science & Technology:Medical Science
关键词
血管紧张素Ⅱ1型受体
基因多态性
原发性高血压
冠心病
angiotensin Ⅱ type 1 receptor
gene polymorphism
essential hypertension
coronary heart disease
