摘要
通过热力学计算证明,超声在生物组织中的粘滞耗散和热耗散引起的吸收低于化学弛豫引起的非经典吸收,低频低强度的超声吸收在生物组织中的熵产生对于癌细胞和正常细胞是不同的,这种不同联系于二者的酸度差异.理论计算证明,低频低强度的超声照射可以导致癌细胞和正常细胞熵产生率的倒转,从而可以改变熵流方向,抑止癌的毒性信息流的扩散.这提供了癌症理疗的一个新方案.
Entropy production of tumor cells is higher than that of normal cells, therefore entropy current is directed from tumor towards healthy cells. However, ultrasound absorption results in additional entropy production in tissues. The differences in ultrasonic absorption are related to pH since tumor is more acidic than normal tissue around the tumor. We demonstrated that the ultrasound absorption will increase the entropy in normal tissue more efficiently than in the tumor. Consequently the direction of entropy flow between two kind of cells may be reversed under the irradiation of ultrasound. Entropy flows from healthy tissue to cancerous tissue after ultrasonic treatment can contribute to the formation of barrier between the two different tissues, blocking the propagation of harmful information of cancer into normal tissue. Based on above studies we suggest that the low intensity （several percents of 1 Watt/cm^2） and low frequency （1 MHz or lower） ultrasound irradiation may be an efficient tool for the physiotherapy of solid tumors.
出处
《内蒙古大学学报（自然科学版）》
CAS
CSCD
北大核心
2006年第4期424-428,共5页
Journal of Inner Mongolia University：Natural Science Edition
基金
国家自然科学基金资助项目(No.90403010)~~
关键词
癌细胞
熵产生率
熵流
超声吸收
化学弛豫
cancerous cell
entropy production
entropy flow
ultrasonic absorption
chemical relaxation
