摘要
目的观察甘氨双唑钠(CMNa)对Ⅲ期非小细胞肺癌(NSCLC)三维适形放疗(3-DCRT)的放射增敏作用及其安全性。方法经病理和细胞学证实的Ⅲ期NSCLC病人42例,随机分为试验组(A组)22例和对照组(B组)20例,B组采用全身伽玛刀放疗,每周5次,每次3.5Gy,总剂量为70Gy。A组采用全身伽玛刀放疗,同时使用CMNa800mgm2,每周5次。结果A组CR率和总有效率(CR+PR)均明显高于B组;A组病人治疗达到PR和CR时的中位照射剂量均低于B组;两组病人不良反应发生率比较无统计学意义。结论CMNa对Ⅲ期非小细胞肺癌三维适形放疗有较肯定的放射增敏作用,明显提高了NSCLC的近期疗效,不增加不良反应。
Objective To observe radiosentization and security of three - dimensional confonnal radiotherapy （3 - DCRT） to non - small cell lung cancer in stage Ⅲ with glycididazole with non - small cell lung cancer in stage Ⅲ were divided into Group natrium （ CMNa）. A （22 cases） and Methods 42 cases Group B （20 cases） randomly. Cases of Group B were treated with whole body Gamma ray, 5 times each week, 3.5Gy per fraction, to a total dose of 70Gy. Cases of Group A were treated with both whole body Gamma ray and CMNa 800mg/m^2 5 times a week. Results Cases of Group A showed more rate of CR and total effective rate （CR ＋ PR） significantly than those of Group B. The median doses by which the effects had reached PR and CR respectively were lower in Group A than in Group B. There was no significant difference between two groups in the rate of adverse reaction. Conclusion CMNa was radiosentizative to non - small cell lung cancer in stage Ⅲ with 3 - DCRT. It could increase immediate response of NSCLC without severe toxicities.
出处
《癌症进展》
2006年第4期358-361,共4页
Oncology Progress
关键词
非小细胞肺癌
三维适形放疗
甘氨双唑钠
放射增敏
non- small cell lung cancer three dimensional conformal radiotherapy glycididazole natrium radiosensitization
