摘要
目的:探讨结直肠癌中P-糖蛋白(P-gp)、谷胱甘肽-S-转移酶(GST-π)和DNA拓扑酶Ⅱ(TopoⅡ)的表达及临床意义。方法:应用SupervisionTM法检测67例结直肠癌组织中P-gp、GST-π和TopoⅡ的表达。结果:P-gp、GST-π和TopoⅡ的表达阳性率分别为64·2%(43/67),59·7%(40/67)和61·2%(41/67)。P-gp、GST-π和TopoⅡ的表达与年龄、性别、肿瘤大小、发病部位、组织学分级、临床分期及有无淋巴结转移无关(P>0·05)。结论:应用免疫组化法检测结直肠癌组织中P-gp、GST-π和TopoⅡ的表达,对结直肠癌的化疗药物的选择和判断预后具有显著的临床意义。
Objective：To evaluate the clinical significance of expression of P-glycoprotein（P-gp）, glutathione S-transferase （GST-π）, and Topoisomerase Ⅱ （Topo Ⅱ ） in colorectal carcinoma. Methods： SupervisionTM immunohistochemical technique was used to examine the expression of P-gp, GST-π, Topo Ⅱ in 67 cases of colorectal carcinoma tissues. Results：The positive rates of expression of P-gp, GST-π, Topo Ⅱ were 64. 2%（43/67） ,59. 7%（40/67） and 61.20%（41/67） ,respectively. The expression rates were not relation to sex, age, tumor site, histological gradee, clinical stage and metastasis of lymph nodes（ P 〉0.05）. Conclusion：The detection of P-gp, GST-πand Topo Ⅱ by immunohistochemstry is of important clinical signifi- cance to select chemotherapy and to judge prognosis in colorectal carcinoma.
出处
《结直肠肛门外科》
2006年第3期137-139,共3页
Journal of Colorectal & Anal Surgery
