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酶催化的立体选择性反应在手性药物合成中的应用 被引量：4

Application of Stereoselective Reactions Catalyzed by Enzyme in Synthesis of Chiral Drugs
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摘要 酶催化的立体选择性反应是当今手性药物合成研究的热点之一,本文按化学反应类型综述了酶催化的水解、酰化、还原、氧化和还原氨化这5种反应在手性药物合成中的应用,重点强调立体选择性。 The stereoselective reactions catalyzed by enzymes are one of the hot topics in synthesis of the chiral drugs. According to chemical reaction type, this article reviewed enzymatic hydrolysis, reduction, acylation and reductive amination in the application of chiral drug synthesis, focusing on the stereoselectivity.
作者 王峥 周伟澄
机构地区 上海医药工业研究院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2006年第7期498-504,共7页 Chinese Journal of Pharmaceuticals
关键词 酶催化 手性药物 合成 应用 综述 enzymatic chiral drugs synthesis application review
分类号 R499 [医药卫生—康复医学]
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参考文献25

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二级参考文献61

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共引文献15

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中国医药工业杂志
2006年 第7期

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