摘要
目的:观察补肾排毒合剂治疗慢性肾衰竭营养不良的疗效。方法:90例慢性肾衰竭营养不良患者随机分为治疗组60例和对照组30例,并设健康对照组30例。治疗组和对照组在综合治疗的基础上,治疗组加用补肾排毒合剂,对照组加用爱西特和百令胶囊。比较两组肾功能、营养状态和血浆瘦素、神经肽Y的变化。结果:治疗组治疗后BUN、Scr明显降低,与治疗前及对照组相比均有统计学差异(P<0.05)。治疗组营养状态好转,与治疗前及对照组相比均有统计学差异(P<0.05)。两组慢性肾衰竭营养不良患者治疗前Leptin、NPY水平均高于健康组(P<0.05),治疗后治疗组Leptin、NPY较治疗前下降,有统计学意义(P<0.05),但与对照组相比无统计学差异(P>0.05)。结论:补肾排毒合剂治疗慢性肾衰竭营养不良疗效明显,可降低BUN、Scr,改善营养不良状态。
Objective： To investigate the effect of Bushen-Paidu Formula（BPF） on CRF patients with malnutrition. Methods： 90 CRF patients with malnutrition were randomly divided into 2 groups： treated group（60）and contral group （30）. And 30 healthy people were chosen as normal control. On the base of general treatment, the treated group were given BPF, and control group were treated by Aixite Tablets and Bailing Capsuls. Blood urine nitrogen （BUN） ,serum creatinine （Ser） and nutrition state were examined in the 2 groups before and after the treatment. The change of Leptin and neuraopeptide Y （NPY） were also examined. All parameters were compared with those in normal group. Results： In BPF treated group, BUN and SCr level decreased while the nutrition state were improved compared with those before the treatment and in control group （P〈0.05 respectively）. All the CRF patients with malnutrition have higher level of serum leptin and NPY than those in normal people （ P 〈 0.05）. The serum leptin and NPY level in treated group decreased after BPF treatment （P〈0. 05）, but there was no significant difference between BPF treated group and control group （P 〉0.05）. Conclusion： BPF is effective for improving nutrition state in CRF patients with malnutrition and can improve renal function.
出处
《中国中西医结合肾病杂志》
2006年第7期395-397,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
青岛市科技局基金资助项目(No.2000ZY02)
关键词
补肾排毒合剂
慢性肾衰竭
营养不良
瘦素
神经肽Y
Bushen-Paidu＇ Formula（BPF） Chronic renal failure（CRF） Malnutrition Leptin Neuropeptide Y（NPY）
